Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution

Overview

Journal Acta Histochem Cytochem

Specialty Biochemistry

Date 2009 Sep 18

PMID 19759870

Citations 9

Authors

Robert Y Osamura

Noboru Egashira

Hanako Kajiya

Mao Takei

Maya Tobita

Takashi Miyakoshi

Chie Inomoto

Susumu Takekoshi

Akira Teramoto

Affiliations

Soon will be listed here.

Abstract

Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2, SF-1. Aberrant expression of transcription factors such as Pit-1 results in translineage expression of GH in adrenocorticotropic hormone-producing adenomas (ACTHomas). This situation has been substantiated by GFP-Pit-1 transfection expression in the AtT20 cell line. Experimentally, GHomas have been induced in GH-releasing hormone (GHRH) or Prop-1 transgenic animals. Immunohistochemical detection of somatostatin receptor (SSTR2a) has recently emphasized their role in the response of GHomas to somatostatin analogue therapy. In this review, the advances in technology and their contribution to cell biology and medical practice are discussed.

Citing Articles

Pathogenesis, clinical features, and treatment of plurihormonal pituitary adenoma.

Cai Y, Liu S, Zhao X, Ren L, Liu X, Gang X Front Neurosci. 2024; 17:1323883.

PMID: 38260014 PMC: 10800528. DOI: 10.3389/fnins.2023.1323883.

High-risk pituitary adenomas and strategies for predicting response to treatment.

Kontogeorgos G, Thodou E, Osamura R, Lloyd R Hormones (Athens). 2022; 21(1):1-14.

PMID: 35061210 DOI: 10.1007/s42000-021-00333-y.

Plurihormonal cells of normal anterior pituitary: Facts and conclusions.

Mitrofanova L, Konovalov P, Krylova J, Polyakova V, Kvetnoy I Oncotarget. 2017; 8(17):29282-29299.

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A Histopathological Study of Multi-hormone Producing Proliferative Lesions in Estrogen-induced Rat Pituitary Prolactinoma.

Takekoshi S, Yasui Y, Inomoto C, Kitatani K, Nakamura N, Osamura R Acta Histochem Cytochem. 2014; 47(4):155-64.

PMID: 25392569 PMC: 4164703. DOI: 10.1267/ahc.14029.

Clinicopathological Features of Growth Hormone-Producing Pituitary Adenomas in 242 Acromegaly Patients: Classification according to Hormone Production and Cytokeratin Distribution.

Mori R, Inoshita N, Takahashi-Fujigasaki J, Joki T, Nishioka H, Abe T ISRN Endocrinol. 2013; 2013:723432.

PMID: 23401791 PMC: 3563234. DOI: 10.1155/2013/723432.

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