[Risks and Side Effects of Blood Transfusion]

Overview

Journal Orthopade

Specialty Orthopedics

Date 2009 Sep 17

PMID 19756492

Authors

B Folsch

U Cassens

Affiliations

Soon will be listed here.

Abstract

While transfusion of blood components is usually safe, there are risks of adverse effects that can have immunologic, nonimmunologic, or infectious causes. In patients, the fear of infectious disease transmission predominates, although the risk has been extremely low since the introduction of reliable serologic and molecular biological testing methods. This article addresses the incidence, clinical picture, and etiology of adverse effects of transfusion. It also reports on current knowledge concerning transfusion-associated acute lung injury, which has gained much attention in the last few years. Besides hepatitis and human immunodeficiency viruses, cytomegalovirus, parvovirus B19, prion transmission, and the risk of variant Creutzfeld-Jakob disease are also discussed.

References

Corcoran A, Doyle S . Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19. J Med Microbiol. 2004; 53(Pt 6):459-475. DOI: 10.1099/jmm.0.05485-0. View

Bux J, Sachs U . Pulmonary transfusion reactions. Transfus Med Hemother. 2011; 35(5):337-45. PMC: 3076325. DOI: 10.1159/000151349. View

Dodd R . Transmission of parasites and bacteria by blood components. Vox Sang. 2000; 78 Suppl 2:239-42. View

Montag T . Strategies of bacteria screening in cellular blood components. Clin Chem Lab Med. 2008; 46(7):926-32. DOI: 10.1515/CCLM.2008.176. View

Strobel E . Hemolytic Transfusion Reactions. Transfus Med Hemother. 2011; 35(5):346-353. PMC: 3076326. DOI: 10.1159/000154811. View

Walther-Wenke G . Incidence of bacterial transmission and transfusion reactions by blood components. Clin Chem Lab Med. 2008; 46(7):919-25. DOI: 10.1515/CCLM.2008.151. View

Sachs U, Bein G . [Transfusion-related acute lung injury (TRALI)]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007; 42(11):774-82. DOI: 10.1055/s-2007-1003590. View

Silliman C, Paterson A, Dickey W, Stroneck D, Popovsky M, Caldwell S . The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study. Transfusion. 1997; 37(7):719-26. DOI: 10.1046/j.1537-2995.1997.37797369448.x. View

Ludlam C, Turner M . Managing the risk of transmission of variant Creutzfeldt Jakob disease by blood products. Br J Haematol. 2005; 132(1):13-24. DOI: 10.1111/j.1365-2141.2005.05796.x. View

10.

Seifried E, Findhammer S, Roth W . Status of NAT screening for HCV, HIV and HBV--experiences of the German Red Cross Blood Donation Services. Dev Biol (Basel). 2002; 108:23-7. View

11.

Popovsky M . Transfusion-Related Acute Lung Injury: Incidence, Pathogenesis and the Role of Multicomponent Apheresis in Its Prevention. Transfus Med Hemother. 2011; 35(2):76-79. PMC: 3076338. DOI: 10.1159/000117811. View

12.

Davis A, Mandal R, Johnson M, Makar R, Stowell C, Dzik S . A touch of TRALI. Transfusion. 2007; 48(3):541-5. DOI: 10.1111/j.1537-2995.2007.01567.x. View

13.

van de Watering L, Brand A . Effects of storage of red cells. Transfus Med Hemother. 2011; 35(5):359-67. PMC: 3076328. DOI: 10.1159/000155221. View

14.

Kiefel V . Reactions Induced by Platelet Transfusions. Transfus Med Hemother. 2011; 35(5):354-358. PMC: 3076327. DOI: 10.1159/000151350. View

15.

Muller T, Mohr H, Montag T . Methods for the detection of bacterial contamination in blood products. Clin Chem Lab Med. 2008; 46(7):933-46. DOI: 10.1515/CCLM.2008.154. View

16.

Hourfar M, Jork C, Schottstedt V, Weber-Schehl M, Brixner V, Busch M . Experience of German Red Cross blood donor services with nucleic acid testing: results of screening more than 30 million blood donations for human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virus. Transfusion. 2008; 48(8):1558-66. DOI: 10.1111/j.1537-2995.2008.01718.x. View

17.

Kleinman S, Caulfield T, Chan P, Davenport R, McFarland J, McPhedran S . Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion. 2004; 44(12):1774-89. DOI: 10.1111/j.0041-1132.2004.04347.x. View