Responses of Blood Vessels in the Rabbit Knee to Electrical Stimulation of the Joint Capsule

Overview

Journal J Physiol

Specialty Physiology

Date 1990 Apr 1

PMID 1974924

Citations 9

Authors

W R Ferrell

A Khoshbaten

Affiliations

Soon will be listed here.

Abstract

1. An in vitro preparation of the rabbit knee joint, perfused with oxygenated Locke's solution, was used to study the response of articular blood vessels to electrical stimulation of the joint capsule. 2. Using trains of stimulus pulses of different durations, frequency-response curves were obtained. Electrical stimulation always produced vasoconstriction of joint blood vessels, which increased as a function of both frequency and pulse width. 3. This vasoconstrictor response was neurally mediated as it was markedly inhibited after addition to both bath and perfusate of tetrodotoxin. In addition, the response to field stimulation of the capsule was virtually abolished in animals pretreated with reserpine which depletes sympathetic nerve endings of noradrenaline. 4. The response to electrical stimulation was substantially reduced by the alpha-adrenergic antagonist phenoxybenzamine (10(-5) M), the alpha 1-blocker prazosin (10(-6) M), and by guanethidine (10(-5) M) which inhibits the release of noradrenaline, ATP and neuropeptide Y from sympathetic nerve endings. 5. The attenuation of the vasoconstrictor response to field stimulation by prazosin (10(-6) M) was little altered by addition of the alpha 2-adrenoceptor blocker rauwolscine (10(-6) M) to the perfusate. 6. alpha, beta-Methylene ATP (10(-6) M), a P2-purinoceptor desensitizer, had no effect on the vasoconstrictor response to electrical stimulation. 7. These results indicate that the vasoconstrictor response to electrical stimulation of the rabbit knee joint capsule is mediated via noradrenaline acting upon alpha 1-adrenoceptors.

Citing Articles

Toward the Existence of a Sympathetic Neuroplasticity Adaptive Mechanism Influencing the Immune Response. A Hypothetical View-Part II.

Bottasso E Front Endocrinol (Lausanne). 2019; 10:633.

PMID: 31620088 PMC: 6760024. DOI: 10.3389/fendo.2019.00633.

Mechanisms of electrical vasoconstriction.

Brinton M, Mandel Y, Schachar I, Palanker D J Neuroeng Rehabil. 2018; 15(1):43.

PMID: 29843762 PMC: 5975571. DOI: 10.1186/s12984-018-0390-y.

Fiber bundle-based integrated platform for wide-field fluorescence imaging and patterned optical stimulation for modulation of vasoconstriction in the deep brain of a living animal.

Kim M, Hong J, Kim J, Shin H Biomed Opt Express. 2017; 8(6):2781-2795.

PMID: 28663906 PMC: 5480429. DOI: 10.1364/BOE.8.002781.

Vasoconstriction by electrical stimulation: new approach to control of non-compressible hemorrhage.

Mandel Y, Manivanh R, Dalal R, Huie P, Wang J, Brinton M Sci Rep. 2013; 3:2111.

PMID: 23828130 PMC: 3701318. DOI: 10.1038/srep02111.

Quantitative analysis of the sympathetic innervation of the rat knee joint.

Catre M, Salo P J Anat. 1999; 194 ( Pt 2):233-9.

PMID: 10337955 PMC: 1467917. DOI: 10.1046/j.1469-7580.1999.19420233.x.

References

Su C . Neurogenic release of purine compounds in blood vessels. J Pharmacol Exp Ther. 1975; 195(1):159-66. View

Nakanishi H, Takeda H . The possibility that adenosine triphosphate is an excitatory transmitter in guinea-pig seminal vesicle. Jpn J Pharmacol. 1972; 22(2):269-70. DOI: 10.1254/jjp.22.269. View

Head R, Stitzel R, de la Lande I, Johnson S . Effect of chronic denervation on the activities of monoamine oxidase and catechol-O-methyl transferase and on the contents of noradrenaline and adenosine triphosphate in the rabbit ear artery. Blood Vessels. 1977; 14(4):229-39. DOI: 10.1159/000158131. View

Su C . Purinergic inhibition of adrenergic transmission in rabbit blood vessels. J Pharmacol Exp Ther. 1978; 204(2):351-61. View

Su C . Modes of vasoconstrictor and vasodilator neurotransmission. Blood Vessels. 1978; 15(1-3):183-9. DOI: 10.1159/000158164. View

Westfall D, Stitzel R, Rowe J . The postjunctional effects and neural release of purine compounds in the guinea-pig vas deferens. Eur J Pharmacol. 1978; 50(1):27-38. DOI: 10.1016/0014-2999(78)90250-9. View

Wakade A, Wakade T . Inhibition of noradrenaline release by adenosine. J Physiol. 1978; 282:35-49. PMC: 1282722. DOI: 10.1113/jphysiol.1978.sp012446. View

de Mey J, Burnstock G, Vanhoutte P . Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP. Eur J Pharmacol. 1979; 55(4):401-5. DOI: 10.1016/0014-2999(79)90115-8. View

Moylan R, Westfall T . Effect of adenosine on adrenergic neurotransmission in the superfused rat portal vein. Blood Vessels. 1979; 16(6):302-10. DOI: 10.1159/000158220. View

10.

Hirst G, Neild T . Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Nature. 1980; 283(5749):767-8. DOI: 10.1038/283767a0. View

11.

Muramatsu I, Fujiwara M, Miura A, Sakakibara Y . Possible involvement of adenine nucleotides in sympathetic neuroeffector mechanisms of dog basilar artery. J Pharmacol Exp Ther. 1981; 216(2):401-9. View

12.

Kasakov L, Burnstock G . The use of the slowly degradable analog, alpha, beta-methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder. Eur J Pharmacol. 1982; 86(2):291-4. DOI: 10.1016/0014-2999(82)90330-2. View

13.

Neild T, Zelcer E . Noradrenergic neuromuscular transmission with special reference to arterial smooth muscle. Prog Neurobiol. 1982; 19(3):141-58. DOI: 10.1016/0301-0082(82)90004-1. View

14.

Langford L, Schmidt R . Afferent and efferent axons in the medial and posterior articular nerves of the cat. Anat Rec. 1983; 206(1):71-8. DOI: 10.1002/ar.1092060109. View

15.

Lundberg J, Anggard A, Pernow J . Guanethidine-sensitive release of neuropeptide Y-like immunoreactivity in the cat spleen by sympathetic nerve stimulation. Neurosci Lett. 1984; 52(1-2):175-80. DOI: 10.1016/0304-3940(84)90370-7. View

16.

Sneddon P, Burnstock G . ATP as a co-transmitter in rat tail artery. Eur J Pharmacol. 1984; 106(1):149-52. DOI: 10.1016/0014-2999(84)90688-5. View

17.

Ferrell W, Khoshbaten A . Adrenoceptor profile of blood vessels in the knee joint of the rabbit. J Physiol. 1989; 414:377-83. PMC: 1189147. DOI: 10.1113/jphysiol.1989.sp017693. View

18.

Cobbold A, Lewis O . The nervous control of joint blood vessels. J Physiol. 1956; 133(2):467-71. PMC: 1359102. DOI: 10.1113/jphysiol.1956.sp005601. View

19.

BURACK W, WEINER N, HAGEN P . The effect of reserpine on the catecholamine and adenine nucleotide contents of adrenal gland. J Pharmacol Exp Ther. 1960; 130:245-50. View

20.

Gardner E . Physiology of movable joints. Physiol Rev. 1950; 30(2):127-76. DOI: 10.1152/physrev.1950.30.2.127. View