Fatal Co-infection with Swine Origin Influenza Virus A/H1N1 and Community-acquired Methicillin-resistant Staphylococcus Aureus

Overview

Journal J Infect

Specialty Infectious Diseases

Date 2009 Sep 15

PMID 19747506

Citations 16

Authors

Vincent C C Cheng

Yuk-Kong Lau

Kwok-Lun Lee

Kwan-Ho Yiu

Kwok-Hung Chan

Pak-Leung Ho

Kwok-Yung Yuen

Affiliations

Soon will be listed here.

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) co-infection has been described previously in association with respiratory tract infection caused by seasonal influenza A viruses, but not with swine origin influenza A (H1N1) virus (S-OIV). We report the clinical and pathological findings of the first death with fulminant co-infection by CA-MRSA. Since early empirical treatment with beta-lactam plus fluoroquinolone or macrolides is often initiated before specimen collections, bacterial co-infection in S-OIV may have been under-reported.

Citing Articles

Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management.

To K, Li I, Hung I, Cheng V, Yuen K Front Med China. 2020; 4(2):147-156.

PMID: 32214991 PMC: 7088550. DOI: 10.1007/s11684-010-0030-9.

Whole-genome sequencing data-based modeling for the investigation of an outbreak of community-associated methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit in Hong Kong.

Cheng V, Wong S, Cao H, Chen J, So S, Wong S Eur J Clin Microbiol Infect Dis. 2019; 38(3):563-573.

PMID: 30680562 DOI: 10.1007/s10096-018-03458-y.

Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene.

Takigawa Y, Fujiwara K, Saito T, Nakasuka T, Ozeki T, Okawa S Intern Med. 2018; 58(5):685-691.

PMID: 30333405 PMC: 6443543. DOI: 10.2169/internalmedicine.1454-18.

Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic.

Hendrickson C, Matthay M Semin Respir Crit Care Med. 2013; 34(4):475-86.

PMID: 23934716 PMC: 4045622. DOI: 10.1055/s-0033-1351122.

Two years after pandemic influenza A/2009/H1N1: what have we learned?.

Cheng V, To K, Tse H, Hung I, Yuen K Clin Microbiol Rev. 2012; 25(2):223-63.

PMID: 22491771 PMC: 3346300. DOI: 10.1128/CMR.05012-11.