Unusual Presentation of Large B Cell Lymphoma- Bone and Stomach- Treated with Autologous Transplantation

Overview

Journal Cancer Res Treat

Specialty Oncology

Date 2009 Sep 12

PMID 19746186

Citations 1

Authors

Bokyung Kim

Sung Yong Oh

Suee Lee

Hyuk-Chan Kwon

Sung-Hyun Kim

Sook Hee Hong

Sung-Soo Kim

Hyo-Jin Kim

Affiliations

Soon will be listed here.

Abstract

Extranodal presentation of diffuse large B cell lymphoma (DLBL) is frequently observed in the gastrointestinal tract, CNS, bone, testes and liver. However, the simultaneous detection of multiple extranodal involvement at presentation is quite an uncommon occurrence. In this study, we report on a patient with an uncommon presentation of DLBL, and he had symptoms of left knee joint pain and hematemesis, characterized by bone and stomach involvement. Computed tomography and fluorodeoxyglucose-positron emission tomography (FDG-PET) scanning revealed a rapid, extensive spread to the bones and soft tissues. Subsequent histopathological examination verified the bony and gastric CD20-positive DLBL localization. We diagnosed this case as DLBL of stage IV with an international prognostic index of 3, and classified him into the high intermediate risk group. This patient was treated via chemotherapy with an R-CHOP regimen. After achieving a partial response, the patient received autologous peripheral blood stem cell transplantation. The patient attained partial remission, as shown on the FDG-PET scan, and he displayed improvement of his left femur pain.

Citing Articles

A 75-Year-Old Female with Dyspnea: An Unusual Presentation of Diffuse Large B-Cell Lymphoma.

Asad S, Mukarram O, Abusaada K Cureus. 2016; 8(9):e801.

PMID: 27790390 PMC: 5081252. DOI: 10.7759/cureus.801.

References

Kuppers R, Klein U, Hansmann M, Rajewsky K . Cellular origin of human B-cell lymphomas. N Engl J Med. 1999; 341(20):1520-9. DOI: 10.1056/NEJM199911113412007. View

Koch P, del Valle F, Berdel W, Willich N, Reers B, Hiddemann W . Primary gastrointestinal non-Hodgkin's lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol. 2001; 19(18):3861-73. DOI: 10.1200/JCO.2001.19.18.3861. View

Economopoulos T, Papageorgiou S, Rontogianni D, Kaloutsi V, Fountzilas G, Tsatalas C . Multifocal extranodal non-hodgkin lymphoma: a clinicopathologic study of 37 cases in Greece, a Hellenic Cooperative Oncology Group study. Oncologist. 2005; 10(9):734-8. DOI: 10.1634/theoncologist.10-9-734. View

DAmore F, Christensen B, BRINCKER H, Pedersen N, Thorling K, Hastrup J . Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas. Danish LYFO Study Group. Eur J Cancer. 1991; 27(10):1201-8. DOI: 10.1016/0277-5379(91)90081-n. View

Economopoulos T, Asprou N, Stathakis N, Fountzilas G, Pavlidis N, Papaspyrou S . Primary extranodal non-Hodgkin's lymphoma of the head and neck. Oncology. 1992; 49(6):484-8. DOI: 10.1159/000227097. View

Shahab N, Doll D . Testicular lymphoma. Semin Oncol. 1999; 26(3):259-69. View

Advani S, Iyer R, Gopal R, Nair C, Saikia T, Dinshaw K . Multifocal extranodal lymphomas: an expression of homing phenomenon. Oncology. 1990; 47(4):334-8. DOI: 10.1159/000226844. View

DAmore F, BRINCKER H, Gronbaek K, Thorling K, Pedersen M, Jensen M . Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis. Danish Lymphoma Study Group. J Clin Oncol. 1994; 12(8):1673-84. DOI: 10.1200/JCO.1994.12.8.1673. View

Widder S, Pasieka J . Primary thyroid lymphomas. Curr Treat Options Oncol. 2004; 5(4):307-13. DOI: 10.1007/s11864-004-0021-7. View

10.

Moller M, Pedersen N, Christensen B . Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation--a population-based study of 1575 cases. Br J Haematol. 2003; 124(2):151-9. DOI: 10.1046/j.1365-2141.2003.04749.x. View

11.

Yuen A, Jacobs C . Lymphomas of the head and neck. Semin Oncol. 1999; 26(3):338-45. View

12.

Eom D, Huh J, Kang Y, Lee Y, Yu E . Clinicopathological features of eight Korean cases of primary hepatic lymphoma. Pathol Int. 2004; 54(11):830-6. DOI: 10.1111/j.1440-1827.2004.01752.x. View

13.

Kadin M, Carpenter C . Systemic and primary cutaneous anaplastic large cell lymphomas. Semin Hematol. 2003; 40(3):244-56. DOI: 10.1016/s0037-1963(03)00138-0. View