Inhibition by Somatostatin of Adenosine-3',5'-monophosphate Stimulated Hepatic Ribosomal Protein Synthesis

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1977 Jul 15

PMID 197300

Citations 2

Authors

K H Tragl

H KINAST

Affiliations

Soon will be listed here.

Abstract

Somatostatin which inhibits the secretion of various pituitary and intestinal hormones has been suspected to exert these effects by inhibiting adenosine-3',5'-monophosphate accumulation in the respective endocrine gland. Our results, obtained by cell free protein synthesis and by sedimentation through sucrose gradients of ribosomes, prepared from rat liver after incubation with cyclic AMP and/or somatostatin also suggest this antagonism between somatostatin and cyclic AMP. In addition, they indicate that this antagonism is not restricted to endocrine tissues.

Citing Articles

Failure of somatostatin to influence experimental tumor cell growth in vivo and in vitro.

Lenzhofer R, Cerni C, Frohlich I, Prager J, Pointner H Experientia. 1981; 37(9):1015-7.

PMID: 6117474 DOI: 10.1007/BF01971812.

Somatostatin reduces the release of colony-stimulating activity (CSA) from PHA-activated mouse spleen lymphocytes.

Hinterberger W, Cerny C, KINAST H, Pointner H, Tragl K Experientia. 1978; 34(7):860-2.

PMID: 307497 DOI: 10.1007/BF01939667.

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