Integrin-mediated Transforming Growth Factor-beta Activation, a Potential Therapeutic Target in Fibrogenic Disorders

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2009 Sep 5

PMID 19729474

Citations 86

Authors

Stephen L Nishimura

Affiliations

Soon will be listed here.

Abstract

A subset of integrins function as cell surface receptors for the profibrotic cytokine transforming growth factor-beta (TGF-beta). TGF-beta is expressed in an inactive or latent form, and activation of TGF-beta is a major mechanism that regulates TGF-beta function. Indeed, important TGF-beta activation mechanisms involve several of the TGF-beta binding integrins. Knockout mice suggest essential roles for integrin-mediated TGF-beta activation in vessel and craniofacial morphogenesis during development and in immune homeostasis and the fibrotic wound healing response in the adult. Amplification of integrin-mediated TGF-beta activation in fibrotic disorders and data from preclinical models suggest that integrins may therefore represent novel targets for antifibrotic therapies.

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