Positive Correlation of PTH-related Peptide with Glucose in Type 2 Diabetes

Overview

Journal Exp Diabetes Res

Specialty Endocrinology

Date 2009 Sep 4

PMID 19727413

Citations 3

Authors

Ioannis Legakis

Timos Mantouridis

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the setting of inadequate beta-cell compensation. Recent studies indicate that for attaining a well-functioning ss-cell mass, parathyroid hormone-related protein (PTHrP) is a very promising candidate among several insulinotropic peptides. In order to elucidate its role, we determine the levels of PTHrP, insulin and c-peptide in type 2 diabetics and in normal subjects in the fasting state. We enrolled 28 patients (16 men and 12 postmenopausal women) with type 2 diabetes and twenty eight aged-matched healthy individuals as control subjects (15 men and 13 women). PTHrP was statistically significant correlated with glucose in type 2 diabetes and in normal subjects in the fasting state. Additionally, PTHrP serum levels exhibited a significant increase in type 2 diabetes compared to control subjects. Interestingly, PTHrP showed a positive correlation with insulin levels only among healthy individuals presumably due to defective glucose stimulated insulin secretion known to occur in type 2 diabetics. In conclusion, the strong positive relation of PTHrP with glucose in the fasting state in patients with type 2 diabetes mellitus raises several questions for further experimentation concerning its exact role and physiological significance.

Citing Articles

The nuclear localization sequence and C-terminus of parathyroid hormone-related protein regulate normal pancreatic islet development and function.

Max-Harry I, Hashmi W, List B, Kantake N, Corbin K, Toribio R Gen Comp Endocrinol. 2023; 340:114309.

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Metabolic Health and Disease: A Role of Osteokines?.

Shimonty A, Bonewald L, Huot J Calcif Tissue Int. 2023; 113(1):21-38.

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The C-terminal fragment of parathyroid hormone-related peptide promotes bone formation in diabetic mice with low-turnover osteopaenia.

Lozano D, Fernandez-de-Castro L, Portal-Nunez S, Lopez-Herradon A, Dapia S, Gomez-Barrena E Br J Pharmacol. 2010; 162(6):1424-38.

PMID: 21175568 PMC: 3058173. DOI: 10.1111/j.1476-5381.2010.01155.x.

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