Albumin--vitamin D-binding Protein Haplotypes in Asian-Pacific Populations

Overview

Journal Hum Genet

Specialty Genetics

Date 1990 Jun 1

PMID 1972697

Citations 1

Authors

L Z Chen

S Easteal

P G Board

K M Summers

K K Bhatia

R L Kirk

Affiliations

Soon will be listed here.

Abstract

We have determined the various haplotypic combinations between alleles as well as restriction fragment length polymorphisms of two linked genetic markers, albumin and vitamin D-binding protein or group-specific component, in a number of Asian-Pacific populations. Using the partial maximum likelihood method, we constructed a phylogenetic network from the haplotype frequencies to assess relationships among the populations sampled. No systematic linkage disequilibrium was detected between most of the combinations, suggesting a lack of operation of any selection pressure at the two loci. The phylogenetic analysis confirmed the known interrelationships among various populations in the Asian-Pacific region. The Australian aborigines clustered closely with the non-Austronesian-speaking highlanders from Papua New Guinea, as expected. Similarly, the Austronesian-speaking Polynesians, Micronesians, and the Southeast Asians branched off together as a separate group. The position of the Austronesian-speaking Tolais from New Britain with respect to other populations from the Southwest Pacific was anomalous. The Tolais revealed a strong affinity with the Australian aborigines, which is inexplicable. The populations from China formed a tight cluster with other populations from the Asian-Pacific region. Genetic interrelationships of these populations with the white Australians were remote, which is in accordance with the known affinities of various human racial groups.

Citing Articles

An ancient common origin of aboriginal Australians and New Guinea highlanders is supported by alpha-globin haplotype analysis.

Martinson J, Norwich J, Harding R, Clegg J, Boettcher B Am J Hum Genet. 1996; 58(5):1017-24.

PMID: 8651262 PMC: 1914625.

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