Neurological and Neurobehavioral Assessment of Experimental Subarachnoid Hemorrhage

Overview

Journal BMC Neurosci

Publisher Biomed Central

Specialty Neurology

Date 2009 Aug 27

PMID 19706182

Citations 52

Authors

Hyojin Jeon

Jinglu Ai

Mohamed Sabri

Asma Tariq

Xueyuan Shang

Gang Chen

R Loch Macdonald

Affiliations

Soon will be listed here.

Abstract

About 50% of humans with aneurysmal subarachnoid hemorrhage (SAH) die and many survivors have neurological and neurobehavioral dysfunction. Animal studies usually focused on cerebral vasospasm and sometimes neuronal injury. The difference in endpoints may contribute to lack of translation of treatments effective in animals to humans. We reviewed prior animal studies of SAH to determine what neurological and neurobehavioral endpoints had been used, whether they differentiated between appropriate controls and animals with SAH, whether treatment effects were reported and whether they correlated with vasospasm. Only a few studies in rats examined learning and memory. It is concluded that more studies are needed to fully characterize neurobehavioral performance in animals with SAH and assess effects of treatment.

Citing Articles

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CDDO, an Anti-Inflammatory and Antioxidant Compound, Attenuates Vasospasm and Neuronal Cell Apoptosis in Rats Subjected to Experimental Subarachnoid Hemorrhage.

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