The Neurobiological Properties of Tianeptine (Stablon): from Monoamine Hypothesis to Glutamatergic Modulation

Overview

Journal Mol Psychiatry

Specialties Molecular Biology
Psychiatry

Date 2009 Aug 26

PMID 19704408

Citations 80

Authors

B S McEwen

S Chattarji

D M Diamond

T M Jay

L P Reagan

P Svenningsson

E Fuchs

Affiliations

Soon will be listed here.

Abstract

Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders.

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