Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP

Overview

Journal Transl Oncol

Specialty Oncology

Date 2009 Aug 25

PMID 19701494

Citations 37

Authors

Thomas Gp Grunewald

Saskia M Pasedag

Elke Butt

Affiliations

Soon will be listed here.

Abstract

Integrating signals from the extracellular matrix through the cell surface into the nucleus is an essential feature of metazoan life. To date, many signal transducers known as shuttle proteins have been identified to act as both a cytoskeletal and a signaling protein. Among them, the most prominent representatives are zyxin and lipoma preferred (translocation) partner (LPP). These proteins belong to the LIM domain protein family and are associated with cell migration, proliferation, and transcription. LPP was first identified in benign human lipomas and was subsequently found to be overexpressed in human malignancies such as lung carcinoma, soft tissue sarcoma, and leukemia. This review portrays LPP in the context of human neoplasia based on a study of the literature to define its important role as a novel protooncogene in carcinogenesis.

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References

Salvi A, Bongarzone I, Micciche F, Arici B, Barlati S, de Petro G . Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells. Neoplasia. 2009; 11(2):207-19. PMC: 2631145. DOI: 10.1593/neo.81076. View

Shepherd T, Kockeritz L, Szrajber M, Muller W, Hassell J . The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol. 2001; 11(22):1739-48. DOI: 10.1016/s0960-9822(01)00536-x. View

Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle M, Golsteyn R . Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. J Biol Chem. 2000; 275(29):22503-11. DOI: 10.1074/jbc.M001698200. View

von Ahsen I, Rogalla P, Bullerdiek J . Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15). Cancer Genet Cytogenet. 2005; 163(1):68-70. DOI: 10.1016/j.cancergencyto.2005.02.023. View

Romanos J, Barisani D, Trynka G, Zhernakova A, Bardella M, Wijmenga C . Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease. J Med Genet. 2008; 46(1):60-3. DOI: 10.1136/jmg.2008.061457. View

Goicoechea S, Arneman D, Otey C . The role of palladin in actin organization and cell motility. Eur J Cell Biol. 2008; 87(8-9):517-25. PMC: 2597190. DOI: 10.1016/j.ejcb.2008.01.010. View

Nilsson M, Mertens F, Hoglund M, Mandahl N, Panagopoulos I . Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15. Cytogenet Genome Res. 2005; 112(1-2):60-6. DOI: 10.1159/000087514. View

Petit M, Crombez K, Vervenne H, Weyns N, Van de Ven W . The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. FEBS Lett. 2005; 579(22):5061-8. DOI: 10.1016/j.febslet.2005.08.012. View

Yi J, Beckerle M . The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics. 1998; 49(2):314-6. DOI: 10.1006/geno.1998.5248. View

10.

Cleynen I, Van de Ven W . The HMGA proteins: a myriad of functions (Review). Int J Oncol. 2008; 32(2):289-305. View

11.

Teg Pipes G, Creemers E, Olson E . The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev. 2006; 20(12):1545-56. DOI: 10.1101/gad.1428006. View

12.

Gorenne I, Jin L, Yoshida T, Sanders J, Sarembock I, Owens G . LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury. Circ Res. 2006; 98(3):378-85. DOI: 10.1161/01.RES.0000202802.34727.fd. View

13.

Grunewald T, Butt E . The LIM and SH3 domain protein family: structural proteins or signal transducers or both?. Mol Cancer. 2008; 7:31. PMC: 2359764. DOI: 10.1186/1476-4598-7-31. View

14.

Huggins C, Andrulis I . Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers. Cancer Lett. 2008; 267(1):55-66. DOI: 10.1016/j.canlet.2008.03.015. View

15.

Otey C, Rachlin A, Moza M, Arneman D, Carpen O . The palladin/myotilin/myopalladin family of actin-associated scaffolds. Int Rev Cytol. 2005; 246:31-58. DOI: 10.1016/S0074-7696(05)46002-7. View

16.

Srichai M, Konieczkowski M, Padiyar A, Konieczkowski D, Mukherjee A, Hayden P . A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. J Biol Chem. 2004; 279(14):14398-408. DOI: 10.1074/jbc.M314155200. View

17.

Honda K, Yamada T, Endo R, Ino Y, Gotoh M, Tsuda H . Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol. 1998; 140(6):1383-93. PMC: 2132673. DOI: 10.1083/jcb.140.6.1383. View

18.

Honda K, Yamada T, Hayashida Y, Idogawa M, Sato S, Hasegawa F . Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology. 2005; 128(1):51-62. DOI: 10.1053/j.gastro.2004.10.004. View

19.

Huggins C, Gill M, Andrulis I . Identification of rare variants in the hLIMD1 gene in breast cancer. Cancer Genet Cytogenet. 2007; 178(1):36-41. DOI: 10.1016/j.cancergencyto.2007.06.007. View

20.

Nerlov C, De Cesare D, PERGOLA F, Caracciolo A, Blasi F, Johnsen M . A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells. EMBO J. 1992; 11(12):4573-82. PMC: 557033. DOI: 10.1002/j.1460-2075.1992.tb05559.x. View