Protection from Oral Herpes Simplex Virus Infection by a Nucleic Acid-free Virus Vaccine

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1977 Jun 1

PMID 197013

Citations 24

Authors

E N Kitces

P S Morahan

J G Tew

B K Murray

Affiliations

Soon will be listed here.

Abstract

The effect of immunization with inactivated herpes virus vaccines, including a vaccine free of all nucleic acid, was investigated in a mouse model system. Protection against oral lesions induced by herpes simplex virus type 1 was demonstrated by several criteria: (i) reduction in the incidence and severity of primary oral lesions; (ii) decrease in acute and latent infection of the regional sensory ganglia; and (iii) protection from viral encephalitis and death. The immune response of mice to the vaccine and to subsequent virus challenge was measured by following serum-neutralizing antibody titers.

Citing Articles

Herpes simplex viruses: is a vaccine tenable?.

Whitley R, Roizman B J Clin Invest. 2002; 110(2):145-51.

PMID: 12122103 PMC: 151069. DOI: 10.1172/JCI16126.

Immune responses to labial infection of BALB/c mice with herpes simplex virus type 1.

Morahan P, Thomson T, Kohl S, Murray B Infect Immun. 1981; 32(1):180-7.

PMID: 7216485 PMC: 350604. DOI: 10.1128/iai.32.1.180-187.1981.

Glycoprotein D protects mice against lethal challenge with herpes simplex virus types 1 and 2.

Long D, Madara T, Ponce de Leon M, Cohen G, Montgomery P, Eisenberg R Infect Immun. 1984; 43(2):761-4.

PMID: 6319291 PMC: 264368. DOI: 10.1128/iai.43.2.761-764.1984.

Comparison of effects of adjuvants on efficacy of virion envelope herpes simplex virus vaccine against labial infection of BALB/c mice.

Thomson T, Hilfenhaus J, Moser H, Morahan P Infect Immun. 1983; 41(2):556-62.

PMID: 6307874 PMC: 264678. DOI: 10.1128/iai.41.2.556-562.1983.

Immune response to a DNA free herpes simplex vaccine in man.

Cappel R, Sprecher S, Rickaert F, de Cuyper F Arch Virol. 1982; 73(1):61-7.

PMID: 6289778 DOI: 10.1007/BF01341728.

References

Kreuter J, SPEISER P . New adjuvants on a polymethylmethacrylate base. Infect Immun. 1976; 13(1):204-10. PMC: 420596. DOI: 10.1128/iai.13.1.204-210.1976. View

Johnson R . THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING. J Exp Med. 1964; 119:343-56. PMC: 2137831. DOI: 10.1084/jem.119.2.343. View

Price R, Walz M, Wohlenberg C, Notkins A . Latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization. Science. 1975; 188(4191):938-40. DOI: 10.1126/science.166432. View

Murray B, Biswal N, Bookout J, Lanford R, Courtney R, Melnick J . Cyclic appearance of defective interfering particles of herpes simplex virus and the concomitant accumulation of early polypeptide VP175. Intervirology. 1975; 5(3-4):173-84. DOI: 10.1159/000149894. View

Zaia J, Palmer E, Feorino P . Humoral and cellular immune responses to an envelope-associated antigen of herpes simplex virus. J Infect Dis. 1975; 132(6):660-6. DOI: 10.1093/infdis/132.6.660. View

Silverman N, Alexander Jr J, HOLLINSHEAD A, Chretien P . Correlation of tumor burden with in vitro lymphocyte reactivity and antibodies to herpesvirus tumor-associated antigens in head and neck squamous carcinoma. Cancer. 1976; 37(1):135-40. DOI: 10.1002/1097-0142(197601)37:1<135::aid-cncr2820370120>3.0.co;2-q. View

Rapp F, Reed C . Experimental evidence for the oncogenic potential of herpes simplex virus. Cancer Res. 1976; 36(2 pt 2):800-6. View

Aurelian L, Strnad B . Herpesvirus type 2-related antigens and their relevance to humoral and cell-mediated immunity in patients with cervical cancer. Cancer Res. 1976; 36(2 pt 2):810-20. View

Melnick J, Courtney R, Powell K, Schaffer P, Melnick M, Dreesman G . Studies on herpes simplex virus and cancer. Cancer Res. 1976; 36(2 pt 2):845-56. View

10.

Notter M, Docherty J . Comparative diagnostic aspects of herpes simplex virus tumor-associated antigens. J Natl Cancer Inst. 1976; 57(3):483-8. DOI: 10.1093/jnci/57.3.483. View

11.

Stevens J, Cook M . Latent herpes simplex virus in spinal ganglia of mice. Science. 1971; 173(3999):843-5. DOI: 10.1126/science.173.3999.843. View

12.

Duff R, Rapp F . Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. Nat New Biol. 1971; 233(36):48-50. DOI: 10.1038/newbio233048a0. View

13.

Kasparov A, MAEVSKAIA T . [Experience with the diagnostic and therapeutic use of herpetic polyvaccine]. Oftalmol Zh. 1972; 27(2):119-24. View

14.

Cook M, Stevens J . Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infect Immun. 1973; 7(2):272-88. PMC: 422671. DOI: 10.1128/iai.7.2.272-288.1973. View

15.

Plummer G . Isolation of herpesviruses from trigeminal ganglia of man, monkeys, and cats. J Infect Dis. 1973; 128(3):345-7. DOI: 10.1093/infdis/128.3.345. View

16.

Nahmias A, Roizman B . Infection with herpes-simplex viruses 1 and 2. 3. N Engl J Med. 1973; 289(15):781-9. DOI: 10.1056/NEJM197310112891505. View

17.

Duff R, Rapp F . Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1. J Virol. 1973; 12(2):209-17. PMC: 356614. DOI: 10.1128/JVI.12.2.209-217.1973. View

18.

Cook M, Bastone V, Stevens J . Evidence that neurons harbor latent herpes simplex virus. Infect Immun. 1974; 9(5):946-51. PMC: 414911. DOI: 10.1128/iai.9.5.946-951.1974. View

19.

Walz M, Price R, Notkins A . Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science. 1974; 184(4142):1185-7. DOI: 10.1126/science.184.4142.1185. View

20.

Murray B, Benyesh-Melnick M, Biswal N . Early and late viral-specific polyribosomal RNA in herpes virus-1 and -2-infected rabbit kidney cells. Biochim Biophys Acta. 1974; 361(2):209-20. DOI: 10.1016/0005-2787(74)90348-7. View