Encephalomyelitis Mimicking Multiple Sclerosis Associated with Chronic Graft-versus-host Disease After Allogeneic Bone Marrow Transplantation

Overview

Journal Intern Med

Specialty General Medicine

Date 2009 Aug 19

PMID 19687597

Citations 23

Authors

Yayoi Matsuo

Kenjiro Kamezaki

Shoichiro Takeishi

Katsuto Takenaka

Tetsuya Eto

Atsushi Nonami

Toshihiro Miyamoto

Hiromi Iwasaki

Naoki Harada

Koji Nagafuji

Takanori Teshima

Koichi Akashi

Affiliations

Soon will be listed here.

Abstract

We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplantation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting of a therapeutic dose of cyclosporine A and a maintenance dose of methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare and remains controversial, presentation of neurological symptoms after allogeneic BMT warrants consideration of GVHD in the differential diagnosis.

Citing Articles

International recommendations for screening and preventative practices for long-term survivors of transplantation and cellular therapy: a 2023 update.

Rotz S, Bhatt N, Hamilton B, Duncan C, Aljurf M, Atsuta Y Bone Marrow Transplant. 2024; 59(6):717-741.

PMID: 38413823 PMC: 11809468. DOI: 10.1038/s41409-023-02190-2.

International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update.

Rotz S, Bhatt N, Hamilton B, Duncan C, Aljurf M, Atsuta Y Transplant Cell Ther. 2024; 30(4):349-385.

PMID: 38413247 PMC: 11181337. DOI: 10.1016/j.jtct.2023.12.001.

Case report: Sudden onset optic neuritis shortly after SARS-CoV-2 vaccination in an allogeneic hematopoietic stem cell transplant recipient with chronic graft-vs.-host disease.

Chu C, Jiang S, Shao Y, Yeh S Front Med (Lausanne). 2023; 10:1177610.

PMID: 37409268 PMC: 10318169. DOI: 10.3389/fmed.2023.1177610.

Possible Chronic Graft-versus-host Disease in the Central Nervous System Manifesting as Cerebellar Ataxia after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.

Takahashi K, Katayama T, Ichikawa T, Matsuoka S, Kakinoki Y, Yoneda M Intern Med. 2022; 62(5):779-786.

PMID: 35945030 PMC: 10037021. DOI: 10.2169/internalmedicine.9720-22.

Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications.

Konen F, Schwenkenbecher P, Jendretzky K, Gingele S, Grote-Levi L, Mohn N Cells. 2022; 11(14).

PMID: 35883607 PMC: 9318423. DOI: 10.3390/cells11142165.