Effectiveness of Combination Use of Antibiotic-loaded PerOssal with Spinal Surgery in Patients with Spondylodiscitis

Overview

Journal Eur Surg Res

Specialty General Surgery

Date 2009 Aug 18

PMID 19684405

Citations 16

Authors

Dietrich von Stechow

M A Rauschmann

Affiliations

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Abstract

Degradable composites of calcium sulphate and nanoparticulate hydroxyapatite (PerOssal) have shown promising results in vitro. Here we investigated the handling, efficacy and compatibility of PerOssal when loaded with gentamicin or vancomycin in 19 patients with spondylodiscitis in vivo. So far, 12 patients who were followed up over at least 1 year have shown a normalization of the infection parameters, no more bone loss in the affected regions and a bony fusion after 3-6 months postoperatively. No revision surgery was related to the use of PerOssal. Locally there were no signs of an ongoing infection. This study demonstrates encouraging results regarding handling, resorption, biocompatibility and antibiotic release using PerOssal pellets in vivo.

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