Enantioselective Synthesis of Beta-trifluoromethyl-beta-lactones Via NHC-catalyzed Ketene-ketone Cycloaddition Reactions

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2009 Aug 18

PMID 19681591

Citations 16

Authors

Xiao-Na Wang

Pan-Lin Shao

Hui Lv

Song Ye

Affiliations

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Abstract

The highly diastereo- and enantioselective synthesis of beta-trifluoromethyl-beta-lactones bearing two contiguous stereocenters was realized by chiral N-heterocyclic carbene-catalyzed formal cycloaddition reaction of alkyl(aryl)ketenes and trifluoromethyl ketones.

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