Role of P38 and JNK in Liver Ischemia and Reperfusion

Overview

Journal J Hepatobiliary Pancreat Surg

Specialties Gastroenterology
General Surgery

Date 2009 Aug 15

PMID 19680593

Citations 28

Authors

LaShonda A King

Alexander H Toledo

Fernando A Rivera-Chavez

Luis H Toledo-Pereyra

Affiliations

Soon will be listed here.

Abstract

Background/purpose: The signal transduction of mitogen-activated protein kinases (MAPKs) has appeared to be an important mediator of ischemic-related events. Because of this, we analyzed the participation of p38 and JNK in liver ischemia and reperfusion, as two individual members of the MAPK family of proteins.

Methods: All papers referred to in PubMed for the past 15 years were analyzed to determine how and when these MAPKs were considered to be an intricate part of the ischemic event. References were cross-studied to ascertain whether other papers could be found in the literature.

Results: The role of p38 and JNK in liver ischemia was confirmed in the literature. The activation of these mediators was associated with the induction of apoptosis and necrosis. Inhibitors of p38 and JNK reduced the liver ischemia and reperfusion damage, probably through the mechanisms mentioned before.

Conclusions: The development of effective inhibitors of p38 and JNK protein mediators is important for minimizing the harmful effects associated with liver ischemia and reperfusion.

Citing Articles

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JNK and p38 gene and protein expression during liver ischemia-reperfusion in a rat model treated with silibinin.

Aamani N, Bagheri A, Masoumi Qajari N, Shafaroudi M, Khonakdar-Tarsi A Iran J Basic Med Sci. 2022; 25(11):1373-1381.

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Mitogen Activated Protein Kinases in Steatotic and Non-Steatotic Livers Submitted to Ischemia-Reperfusion.

Jimenez-Castro M, Cornide-Petronio M, Gracia-Sancho J, Casillas-Ramirez A, Peralta C Int J Mol Sci. 2019; 20(7).

PMID: 30974915 PMC: 6479363. DOI: 10.3390/ijms20071785.

Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways.

Deng J, Feng J, Liu T, Lu X, Wang W, Liu N Drug Des Devel Ther. 2018; 12:4067-4082.

PMID: 30568428 PMC: 6276616. DOI: 10.2147/DDDT.S182292.

Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study.

Ishikawa T, Shimada S, Fukai M, Kimura T, Umemoto K, Shibata K Surg Today. 2018; 48(12):1081-1088.

PMID: 29980846 DOI: 10.1007/s00595-018-1693-0.