Retroelements and Their Impact on Genome Evolution and Functioning

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2009 Aug 4

PMID 19649766

Citations 60

Authors

Elena Gogvadze

Anton Buzdin

Affiliations

Soon will be listed here.

Abstract

Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes of almost all organisms. First considered as a "junk DNA" or genomic parasites, they were shown to influence genome functioning and to promote genetic innovations. For this reason, they were suggested as an important creative force in the genome evolution and adaptation of an organism to altered environmental conditions. In this review, we summarize the up-to-date knowledge of different ways of retroelement involvement in structural and functional evolution of genes and genomes, as well as the mechanisms generated by cells to control their retrotransposition.

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