» Articles » PMID: 19645580

Effect of Firocoxib or Flunixin Meglumine on Recovery of Ischemic-injured Equine Jejunum

Overview
Journal Am J Vet Res
Date 2009 Aug 4
PMID 19645580
Citations 19
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: To determine whether treatment of horses with firocoxib affects recovery of ischemic-injured jejunum, while providing effective analgesia.

Animals: 18 horses.

Procedures: Horses (n = 6 horses/group) received saline (0.9% NaCl) solution (1 mL/50 kg, IV), flunixin meglumine (1.1 mg/kg, IV, q 12 h), or firocoxib (0.09 mg/kg, IV, q 24 h) before 2 hours of jejunal ischemia. Horses were monitored via pain scores and received butorphanol for analgesia. After 18 hours, ischemic-injured and control mucosa were placed in Ussing chambers for measurement of transepithelial resistance and permeability to lipopolysaccharide. Histomorphometry was used to determine denuded villus surface area. Western blots for cyclooxygenase (COX)-1 and COX-2 were performed. Plasma thromboxane B(2) and prostaglandin E(2) metabolite (PGEM) concentrations were determined.

Results: Pain scores did not significantly increase after surgery in horses receiving flunixin meglumine or firocoxib. Transepithelial resistance of ischemic-injured jejunum from horses treated with flunixin meglumine was significantly lower than in saline- or firocoxib-treated horses. Lipopolysaccharide permeability across ischemic-injured mucosa was significantly increased in horses treated with flunixin meglumine. Treatment did not affect epithelial restitution. Cyclooxygenase-1 was constitutively expressed and COX-2 was upregulated after 2 hours of ischemia. Thromboxane B(2) concentration decreased with flunixin meglumine treatment but increased with firocoxib or saline treatment. Flunixin meglumine and firocoxib prevented an increase in PGEM concentration after surgery.

Conclusions And Clinical Relevance: Flunixin meglumine retarded mucosal recovery in ischemic-injured jejunum, whereas firocoxib did not. Flunixin meglumine and firocoxib were effective visceral analgesics. Firocoxib may be advantageous in horses recovering from ischemic intestinal injury.

Citing Articles

Assessment of equine intestinal epithelial junctional complexes and barrier permeability using a monolayer culture system.

Stewart A, Kopper J, McKinney-Aguirre C, Veerasamy B, Sahoo D, Freund J Front Vet Sci. 2024; 11:1455262.

PMID: 39502947 PMC: 11536341. DOI: 10.3389/fvets.2024.1455262.


Hematological and Biochemical Effects Associated with Prolonged Administration of the NSAID Firocoxib in Adult Healthy Horses.

Ignacio F, Garcia L, de Souza G, Amatti L, de Barros L, Bergfelt D Vet Sci. 2024; 11(6).

PMID: 38922003 PMC: 11209463. DOI: 10.3390/vetsci11060256.


Analgesic Efficacy of Non-Steroidal Anti-Inflammatory Drug Therapy in Horses with Abdominal Pain: A Systematic Review.

Citarella G, Heitzmann V, Ranninger E, Bettschart-Wolfensberger R Animals (Basel). 2023; 13(22).

PMID: 38003065 PMC: 10668864. DOI: 10.3390/ani13223447.


Safety Assessment of an Oral Therapeutic Dose of Firocoxib on Healthy Horses.

Araujo R, Sales N, Basile R, Feringer-Junior W, Apparicio M, Ferraz G Vet Sci. 2023; 10(9).

PMID: 37756053 PMC: 10535825. DOI: 10.3390/vetsci10090531.


Synopsis of the pharmacokinetics, pharmacodynamics, applications, and safety of firocoxib in horses.

Fadel C, Giorgi M Vet Anim Sci. 2023; 19:100286.

PMID: 36684818 PMC: 9852958. DOI: 10.1016/j.vas.2023.100286.