Tumor-associated Epilepsy and Glioma: Are There Common Genetic Pathways?

Overview

Journal Acta Oncol

Specialty Oncology

Date 2009 Jul 30

PMID 19639468

Citations 18

Authors

Shala Ghaderi Berntsson

Beatrice Malmer

Melissa L Bondy

Mingqi Qu

Anja Smits

Affiliations

Soon will be listed here.

Abstract

Background: Patients with glioma exhibit a great variability in clinical symptoms apart from variations in response to therapy and survival. Many patients present with epileptic seizures at disease onset, especially in case of low-grade gliomas, but not all have seizures. A large proportion of patients develop refractory seizures. It is likely that the variability in epileptic symptoms cannot exclusively be explained by tumor-related factors, but rather reflects complex interaction between tumor-related, environmental and hereditary factors.

Material And Methods: No data exist on susceptibility genes associated with epileptic symptoms in patients with glioma. However, an increasing number of candidate genes have been proposed for other focal epilepsies such as temporal lobe epilepsy. Some of the susceptibility candidate genes associated with focal epilepsy may contribute to epileptic symptoms also in patients with glioma.

Results: This review presents an update on studies on genetic polymorphisms and focal epilepsy and brings forward putative candidate genes for tumor-associated epilepsy, based on the assumption that common etiological pathways may exist for glioma development and glioma-associated seizures. Conclusion. Genes involved in the immune response, in synaptic transmission and in cell cycle control are discussed that may play a role in the pathogenesis of tumor growth as well as epileptic symptoms in patients with gliomas.

Citing Articles

Molecular mechanisms and diagnostic model of glioma-related epilepsy.

Li J, Long S, Zhang Y, Wei W, Yu S, Liu Q NPJ Precis Oncol. 2024; 8(1):223.

PMID: 39363097 PMC: 11450052. DOI: 10.1038/s41698-024-00721-8.

[Epilepsy in cancer patients: primary prevention and the importance of high-risk patient screening].

Lopez-Anguita S, Gutierrez-Ruano B, Munoz-Gonzalez A, Valenzuela-Rojas F, Olmedilla-Gonzalez M Rev Neurol. 2022; 75(11):349-356.

PMID: 36440747 PMC: 10280744. DOI: 10.33588/rn.7511.2022200.

Correlation of Clinicopathological Factors with Brain Tumor-Related Epilepsy in Glioma.

Wang Z, Yang W, Wang Y, Aili Y, Wang Z, Wang Q Dis Markers. 2022; 2022:4918294.

PMID: 36246555 PMC: 9553557. DOI: 10.1155/2022/4918294.

Old Stars and New Players in the Brain Tumor Microenvironment.

Parmigiani E, Scalera M, Mori E, Tantillo E, Vannini E Front Cell Neurosci. 2021; 15:709917.

PMID: 34690699 PMC: 8527006. DOI: 10.3389/fncel.2021.709917.

Development of a Rat Model for Glioma-Related Epilepsy.

Bouckaert C, Germonpre C, Verhoeven J, Chong S, Jacquin L, Mairet-Coello G Int J Mol Sci. 2020; 21(19).

PMID: 32977526 PMC: 7582710. DOI: 10.3390/ijms21196999.

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