The Common Biological Basis for Common Complex Diseases: Evidence from Lipoprotein Lipase Gene

Overview

Journal Eur J Hum Genet

Specialty Genetics

Date 2009 Jul 30

PMID 19639021

Citations 14

Authors

Cui Xie

Zeng Chan Wang

Xiao Feng Liu

Mao Sheng Yang

Affiliations

Soon will be listed here.

Abstract

The lipoprotein lipase (LPL) gene encodes a rate-limiting enzyme protein that has a key role in the hydrolysis of triglycerides. Hypertriglyceridemia, one widely prevalent syndrome of LPL deficiency and dysfunction, may be a risk factor in the development of dyslipidemia, type II diabetes (T2D), essential hypertension (EH), coronary heart disease (CHD) and Alzheimer's disease (AD). Findings from earlier studies indicate that LPL may have a role in the pathology of these diseases and therefore is a common or shared biological basis for these common complex diseases. To examine this hypothesis, we reviewed articles on the molecular structure, expression and function of the LPL gene, and its potential role in the etiology of diseases. Evidence from these studies indicate that LPL dysfunction is involved in dyslipidemia, T2D, EH, CHD and AD; and support the hypothesis that there is a common or shared biological basis for these common complex diseases.

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