Proanthocyanidin to Prevent Formation of the Reexpansion Pulmonary Edema

Overview

Journal J Cardiothorac Surg

Publisher Biomed Central

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2009 Jul 30

PMID 19638221

Citations 3

Authors

Orhan Yucel

Ergun Ucar

Ergun Tozkoparan

Armagan Gunal

Cemal Akay

Mehmet Ali Sahin

Onur Genc

Affiliations

Soon will be listed here.

Abstract

Background: We aimed to investigate the preventive effect of Proanthocyanidine (PC) in the prevention of RPE formation.

Methods: Subjects were divided into four groups each containing 10 rats. In the Control Group (CG): RPE wasn't performed. Then subjects were followed up for three days and they were sacrificed after the follow up period. Samplings were made from tissues for measurement of biochemical and histopathologic parameters. In the Second Group (PCG): The same protocol as CG was applied, except the administration of PC to the subjects. In the third RPE Group (RPEG): Again the same protocol as CG was applied, but as a difference, RPE was performed. In the Treatment Group (TG): The same protocol as RPEG was applied except the administration of PC to the subjects.

Results: In RPEG group, the most important histopathological finding was severe pulmonary edema with alveolar damage and acute inflammatory cells. These findings were less in the TG group. RPE caused increased MDA levels, and decreased GPx, SOD and CAT activity significantly in lung tissue.

Conclusion: PC decreased MDA levels. Oxidative stress plays an important role in pathophysiology of RPE and PC treatment was shown to be useful to prevent formation of RPE.

Citing Articles

Investigation of the preventive effect of proanthocyanidin in ischemia-reperfusion injury in lung transplantation: An experimental study.

Sapmaz E, Caylak H, Kavakli K, Gamsizkan M, Sirin Y, Genc O Turk Gogus Kalp Damar Cerrahisi Derg. 2020; 26(4):606-613.

PMID: 32082803 PMC: 7018171. DOI: 10.5606/tgkdc.dergisi.2018.16078.

A common gesture with a rare but potentially severe complication: Re-expansion pulmonary edema following chest tube drainage.

Kepka S, Lemaitre L, Marx T, Bilbault P, Desmettre T Respir Med Case Rep. 2019; 27:100838.

PMID: 31016133 PMC: 6475766. DOI: 10.1016/j.rmcr.2019.100838.

Reexpansion pulmonary edema after chest drainage for pneumothorax: A case report and literature overview.

Verhagen M, van Buijtenen J, Geeraedts Jr L Respir Med Case Rep. 2015; 14:10-2.

PMID: 26029567 PMC: 4356048. DOI: 10.1016/j.rmcr.2014.10.002.

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