Virological and Epitope Evolution of HCV Infection from Acute Hepatitis C to Subsequent Episodes of HCV-related Acute Liver Cell Necrosis

Overview

Journal Infection

Date 2009 Jul 29

PMID 19636498

Citations 3

Authors

E Sagnelli

C Argentini

D Genovese

M Pisaturo

N Coppola

S Taffon

C Sagnelli

M Rapicetta

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the virological and clinical events occurring during a 3-year follow-up in three patients who, after symptomatic acute hepatitis C (AHC), experienced subsequent episodes of HC virus (V)-related acute liver cell necrosis.

Patients And Methods: The three patients were investigated for viral variability in the core, E1/E2, and NS5b regions during different phases of infection, and a computer-assisted analysis of the variation of known predicted epitopes in the consensus sequence was performed.

Results: The first patient showed numerous genetic variations, which may be related to the maintenance of a chronic HCV infection state and to episodes of liver disease exacerbation. The second patient showed minimal viral variations associated with apparent resolution of the infection, but the same virus isolate, based on phylogenetic analysis, produced a second acute episode after the occult phase. The third patient, after the resolution of AHC, manifested a second episode of HCV infection by a different HCV sub-genotype.

Conclusion: Episodes of HCV-related acute liver cell necrosis after AHC may be associated to different virological patterns, such as the establishment of a chronic HCV infection, a reactivation of an occult virus, or a reinfection by a different HCV genotype.

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References

Proust B, Dubois F, Bacq Y, Le Pogam S, Rogez S, Levillain R . Two successive hepatitis C virus infections in an intravenous drug user. J Clin Microbiol. 2000; 38(8):3125-7. PMC: 87209. DOI: 10.1128/JCM.38.8.3125-3127.2000. View

BOOTH J, Kumar U, Webster D, MONJARDINO J, Thomas H . Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients. Hepatology. 1998; 27(1):223-7. DOI: 10.1002/hep.510270134. View

Castillo I, Rodriguez-Inigo E, Lopez-Alcorocho J, Pardo M, Bartolome J, Carreno V . Hepatitis C virus replicates in the liver of patients who have a sustained response to antiviral treatment. Clin Infect Dis. 2006; 43(10):1277-83. DOI: 10.1086/508198. View

Afdhal N . The natural history of hepatitis C. Semin Liver Dis. 2004; 24 Suppl 2:3-8. DOI: 10.1055/s-2004-832922. View

Castillo I, Rodriguez-Inigo E, Bartolome J, de Lucas S, Ortiz-Movilla N, Lopez-Alcorocho J . Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection. Gut. 2005; 54(5):682-5. PMC: 1774478. DOI: 10.1136/gut.2004.057281. View

Sheen I, Liaw Y, Lin D, Chu C . Acute exacerbations in chronic hepatitis C: a clinicopathological and prognostic study. J Hepatol. 1996; 24(5):525-31. DOI: 10.1016/s0168-8278(96)80136-x. View

Jarvis L, Watson H, McOmish F, Peutherer J, Ludlam C, Simmonds P . Frequent reinfection and reactivation of hepatitis C virus genotypes in multitransfused hemophiliacs. J Infect Dis. 1994; 170(4):1018-22. DOI: 10.1093/infdis/170.4.1018. View

Weiner A, Geysen H, Christopherson C, Hall J, Mason T, Saracco G . Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci U S A. 1992; 89(8):3468-72. PMC: 48889. DOI: 10.1073/pnas.89.8.3468. View

Dove L, Phung Y, Bzowej N, Kim M, Monto A, Wright T . Viral evolution of hepatitis C in injection drug users. J Viral Hepat. 2005; 12(6):574-83. DOI: 10.1111/j.1365-2893.2005.00640.x. View

10.

Sagnelli E, Coppola N, Marrocco C, Coviello G, Battaglia M, Messina V . Diagnosis of hepatitis C virus related acute hepatitis by serial determination of IgM anti-HCV titres. J Hepatol. 2005; 42(5):646-51. DOI: 10.1016/j.jhep.2004.12.027. View

11.

Farci P, Shimoda A, Coiana A, Diaz G, Peddis G, Melpolder J . The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science. 2000; 288(5464):339-44. DOI: 10.1126/science.288.5464.339. View

12.

Grebely J, Conway B, Raffa J, Lai C, Krajden M, Tyndall M . Hepatitis C virus reinfection in injection drug users. Hepatology. 2006; 44(5):1139-45. DOI: 10.1002/hep.21376. View

13.

Rumi M, De Filippi F, La Vecchia C, Donato M, Gallus S, Del Ninno E . Hepatitis C reactivation in patients with chronic infection with genotypes 1b and 2c: a retrospective cohort study of 206 untreated patients. Gut. 2005; 54(3):402-6. PMC: 1774395. DOI: 10.1136/gut.2004.048009. View

14.

ISHAK K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F . Histological grading and staging of chronic hepatitis. J Hepatol. 1995; 22(6):696-9. DOI: 10.1016/0168-8278(95)80226-6. View

15.

Kumar S, Tamura K, Nei M . MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform. 2004; 5(2):150-63. DOI: 10.1093/bib/5.2.150. View

16.

Castillo I, Pardo M, Bartolome J, Ortiz-Movilla N, Rodriguez-Inigo E, de Lucas S . Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis. 2004; 189(1):7-14. DOI: 10.1086/380202. View

17.

Lai M, Mazzoleni A, Argiolu F, De Virgilis S, Balestrieri A, Purcell R . Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children. Lancet. 1994; 343(8894):388-90. DOI: 10.1016/s0140-6736(94)91224-6. View

18.

Hiraga N, Suzuki F, Akuta N, Suzuki Y, Sezaki H, Hosaka T . Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up. J Med Virol. 2004; 75(2):240-8. DOI: 10.1002/jmv.20263. View

19.

RAMMENSEE H, Bachmann J, Emmerich N, Bachor O, Stevanovic S . SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics. 1999; 50(3-4):213-9. DOI: 10.1007/s002510050595. View

20.

Coppola N, Vatiero L, Sagnelli E . HCV genotype 2 as a risk factor for reactivation of chronic HCV infection. Gut. 2005; 54(8):1207. PMC: 1774891. DOI: 10.1136/gut.2005.070649. View