Vascular Complications After Splenectomy for Hematologic Disorders

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2009 Jul 29

PMID 19636061

Citations 102

Authors

Shelley E Crary

George R Buchanan

Affiliations

Soon will be listed here.

Abstract

The most widely recognized long-term risk of splenectomy is overwhelming bacterial infection. More recently, thrombosis has become appreciated as another potential complication of the procedure. Because of these long-term risks, the indications for and timing of splenectomy are debated in the medical community. Accordingly, the adverse effects and benefits of splenectomy for hematologic disorders and other conditions demand further study. This comprehensive review summarizes the existing literature pertaining to vascular complications after splenectomy for hematologic conditions and attempts to define the potential pathophysiologic mechanisms involved. This complex topic encompasses diverse underlying conditions for which splenectomy is performed, diverse thrombotic complications, and multiple pathophysiologic mechanisms.

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