Nonspecific Lymphocytic Myocarditis in Baboons is Associated with Trypanosoma Cruzi Infection

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2009 Jul 29

PMID 19635876

Citations 13

Authors

Marcia C R Andrade

Edward J Dick Jr

Rodolfo Guardado-Mendoza

Michaelle L Hohmann

Diana C P Mejido

John L VandeBerg

Cheryl D DiCarlo

Gene B Hubbard

Affiliations

Soon will be listed here.

Abstract

Non-specific lymphocytic myocarditis (NLM) is frequently observed in baboons within the endemic range of Trypanosoma cruzi. We sought to determine whether T. cruzi infection is a cause of baboon NLM. We evaluated serial histologic sections of cardiac muscle, blood cultures, immunohistochemistry, serology, polymerase chain reaction, and clinical pathology from 31 baboons with NLM to determine whether T. cruzi infection is associated with NLM. Eleven baboons with no evidence of T. cruzi infection by serology and no NLM were used as controls. Seropositivity for T. cruzi was 45% in baboons with NLM compared with a 2-3% colony prevalence. NLM lesion severity was significantly higher in seropositive than seronegative baboons with NLM. NLM was significantly more common in older baboons. No statistical association between NLM and sex, weight, or clinical pathology was found. These results suggest an association between NLM and T. cruzi infection in the baboon.

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