Sennetsu Neorickettsiosis: a Probable Fish-borne Cause of Fever Rediscovered in Laos

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2009 Jul 29

PMID 19635868

Citations 12

Authors

Paul N Newton

Jean-Marc Rolain

Bouachanh Rasachak

Mayfong Mayxay

Khamtanh Vathanatham

Piseth Seng

Rattanaphone Phetsouvanh

Te Thammavong

Jamaayah Zahidi

Yupin Suputtamongkol

Bounkong Syhavong

Didier Raoult

Affiliations

Soon will be listed here.

Abstract

Neorickettsia sennetsu has been described from Japan and Malaysia, causing a largely forgotten infectious mononucleosis-like disease. Because it is believed to be contracted from eating raw fish, frequently consumed in the Lao PDR, we looked for evidence of N. sennetsu among Lao patients and fish. A buffy coat from 1 of 91 patients with undifferentiated fever was positive by 16S rRNA amplification and sequencing and real-time polymerase chain reactions (PCR) targeting two N. sennetsu genes. Lao blood donors and patients with fever, hepatitis, or jaundice (N = 1,132) had a high prevalence (17%) of immunofluorescence assay IgG anti-N. sennetsu antibodies compared with 4% and 0% from febrile patients (N = 848) in Thailand and Malaysia, respectively. We found N. sennetsu DNA by PCR, for the first time, in a fish (Anabas testudineus). These data suggest that sennetsu may be an under-recognized cause of fever and are consistent with the hypothesis that it may be contracted from eating raw fish.

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