Cell Death: a New Par-4 the TRAIL

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2009 Jul 28

PMID 19632170

Citations 5

Authors

Lori S Hart

Wafik S El-Deiry

Affiliations

Soon will be listed here.

Abstract

The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also promote apoptosis from outside the cell, after its secretion in response to endoplasmic reticulum stress.

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Targeting apoptosis in cancer therapy.

Carneiro B, El-Deiry W Nat Rev Clin Oncol. 2020; 17(7):395-417.

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A journey beyond apoptosis: new enigma of controlling metastasis by pro-apoptotic Par-4.

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IRES-Dependent Translational Control during Virus-Induced Endoplasmic Reticulum Stress and Apoptosis.

Hanson P, Zhang H, Hemida M, Ye X, Qiu Y, Yang D Front Microbiol. 2012; 3:92.

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The Par-4-GRP78 TRAIL, more twists and turns.

Lee A Cancer Biol Ther. 2009; 8(22):2103-5.

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