The Y's That Bind: Negative Regulators of Src Family Kinase Activity in Platelets

Overview

Journal J Thromb Haemost

Publisher Elsevier

Specialty Hematology

Date 2009 Jul 28

PMID 19630799

Citations 8

Authors

D K Newman

Affiliations

Soon will be listed here.

Abstract

Members of the Src family of protein tyrosine kinases play important roles in platelet adhesion, activation, and aggregation. The purpose of this review is to summarize current knowledge regarding how Src family kinase activity is regulated in general, to describe what is known about mechanisms underlying SFK activation in platelets, and to discuss platelet proteins that contribute to SFK inactivation, particularly those that use phosphotyrosine-containing sequences to recruit phosphatases and kinases to sites of SFK activity.

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