Imaging of Congenital Mesoblastic Nephroma with Pathological Correlation

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 2009 Jul 25

PMID 19629463

Citations 11

Authors

Gulraiz Chaudry

Antonio R Perez-Atayde

Bo Yee Ngan

Munire Gundogan

Alan Daneman

Affiliations

Soon will be listed here.

Abstract

Background: There are a variety of imaging findings for congenital mesoblastic nephroma (CMN) and two main pathological variants: classic and cellular.

Objective: To determine whether imaging findings in children can predict the likely pathological variant.

Materials And Methods: We reviewed imaging in children with pathology-proven CMN. Imaging findings correlated with gross and histological appearance.

Results: In 15 boys and 15 girls with CMN, US was performed in 27, CT in 19, and MRI in 7. Cystic components were readily identified on US; central hemorrhage was better differentiated on CT. MRI demonstrated high sensitivity for both. Histology confirmed classic CMN in 13 children, cellular CMN in 14 and "mixed" CMN in 3. Age at presentation was significantly higher in children with the cellular variant. Of 15 solid or predominantly solid tumors and 10 lesions with a hypoechoic ring, 12 and 7, respectively, had pathology consistent with classic CMN. In contrast, five of seven with intratumoral hemorrhage and all with a large cystic/necrotic component had pathology consistent with the cellular variant.

Conclusion: The imaging appearance of CMN is often determined by the pathological type of tumor. Findings suggestive of the classic variant include a peripheral hypoechoic ring or large solid component. In comparison, cystic/necrotic change and hemorrhage is much more common in cellular CMN.

Citing Articles

Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study.

van der Beek J, Schenk J, Morosi C, Watson T, Coma A, Graf N Pediatr Radiol. 2024; 54(6):965-976.

PMID: 38609702 PMC: 11111520. DOI: 10.1007/s00247-024-05918-4.

Report and follow-up on two new patients with congenital mesoblastic nephroma.

Serra G, Cimador M, Giuffre M, Insinga V, Montante C, Pensabene M Ital J Pediatr. 2023; 49(1):124.

PMID: 37726782 PMC: 10510132. DOI: 10.1186/s13052-023-01523-7.

Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children.

Ayaz E, Ozcan H, Oguz B, Haliloglu M Pediatr Radiol. 2022; 52(13):2557-2567.

PMID: 35760918 DOI: 10.1007/s00247-022-05422-7.

Cellular congenital mesoblastic nephroma detected by prenatal MRI: a case report and literature review.

Liu T, Al-Kzayer L, Sarsam S, Chen L, Saeed R, Ali K Transl Pediatr. 2022; 11(1):163-173.

PMID: 35242663 PMC: 8825936. DOI: 10.21037/tp-21-289.

[Imaging of abdominal tumors in childhood and adolescence : Part II: relevant intra-abdominal and retroperitoneal tumor entities].

Renz D, Mentzel H Radiologe. 2018; 58(7):673-686.

PMID: 29947934 DOI: 10.1007/s00117-018-0410-8.

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