Nosocomial Sepsis Risk Score for Preterm Infants in Low-resource Settings

Overview

Journal J Trop Pediatr

Specialties Pediatrics
Tropical Medicine

Date 2009 Jul 23

PMID 19622712

Citations 13

Authors

Rebecca E Rosenberg

A S M Nawshad U Ahmed

Samir K Saha

M A K Azad Chowdhury

Saifuddin Ahmed

Paul A Law

Robert E Black

Mathuram Santosham

Gary L Darmstadt

Affiliations

Soon will be listed here.

Abstract

Sepsis is a leading cause of mortality for neonates in developing countries; however, little research has focused on clinical predictors of nosocomial infection of preterm neonates in the low-resource setting. We sought to validate the only existing feasible score introduced by Singh et al. in 2003 and to create an improved score. In a secondary analysis of daily evaluations of 497 neonates <or=33 weeks gestational age admitted to a tertiary care NICU in Dhaka, Bangladesh, we tested the Singh score and then constructed and internally validated our own bedside predictive score. The Singh score had low sensitivity of 56.6% but good positive predictive value (PPV) of 78.1% in our sample. Our five-sign model requiring at least one clinical sign of infection (apnea, hepatomegaly, jaundice, lethargy and pallor) had an area under the receiver operating characteristic of 0.70, sensitivity of 77.1%, and PPV of 64.9%. Our clinical sepsis score is the first bedside clinical screen exclusively for hospitalized, very premature neonates in a low-resource setting, and warrants external validation.

Citing Articles

Neonatal Sepsis: A Comprehensive Review.

Kariniotaki C, Thomou C, Gkentzi D, Panteris E, Dimitriou G, Hatzidaki E Antibiotics (Basel). 2025; 14(1).

PMID: 39858292 PMC: 11761862. DOI: 10.3390/antibiotics14010006.

Multicentre external validation of the Neonatal Healthcare-associated infectiOn Prediction (NeoHoP) score: a retrospective case-control study.

Lloyd L, Dramowski A, Bekker A, Ballot D, Ferreyra C, Gleeson B BMJ Paediatr Open. 2024; 8(1).

PMID: 39353711 PMC: 11448137. DOI: 10.1136/bmjpo-2024-002748.

Development and internal validation of a Neonatal Healthcare-associated infectiOn Prediction score (NeoHoP score) for very low birthweight infants in low-resource settings: a retrospective case-control study.

Lloyd L, van Weissenbruch M, Dramowski A, Gleeson B, Ferreyra C, Bekker A BMJ Paediatr Open. 2023; 7(1).

PMID: 37550083 PMC: 10407408. DOI: 10.1136/bmjpo-2023-002056.

Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS).

Russell N, Stohr W, Plakkal N, Cook A, Berkley J, Adhisivam B PLoS Med. 2023; 20(6):e1004179.

PMID: 37289666 PMC: 10249878. DOI: 10.1371/journal.pmed.1004179.

Early Diagnosis of Late-Onset Neonatal Sepsis Using a Sepsis Prediction Score.

Sofouli G, Tsintoni A, Fouzas S, Vervenioti A, Gkentzi D, Dimitriou G Microorganisms. 2023; 11(2).

PMID: 36838200 PMC: 9964338. DOI: 10.3390/microorganisms11020235.

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