Influence of Electromagnetic Fields on Bone Fracture in Rats: Role of CAPE

Objective: To study the effects of radiation emitted by mobile phones on bone strength and caffeic acid phenethyl ester (CAPE) on the changes induced by radiation.

Methods: Forty-eight Sprague-Dawley rats were divided into five groups. Rats in the control group (first group) were left within the experimental setup for 30 min/day for 28 days without radiation exposure. Nine hundred MHz radiation group was broke down into 2 subgroups (group 1/2). Both subgroups were exposed to radiation for 28 days (30 min/day). The next group was also divided into 2 subgroups (group 3/4). Each was exposed to 1800 MHz of radiation for 28 days (30 min/day). The third and fifth groups were also treated with CAPE for 28 days. Treatment groups received ip caffeic acid phenethyl ester (10 micromol/kg per day) before radiation session. Bone fracture was analyzed.

Results: Breaking force, bending strength, and total fracture energy decreased in the irradiated groups but increased in the treatment groups.

Conclusion: Radiation and CAPE can significantly improve bone.