Forces and Structural Limitations of Binding of Thyrotrophin-releasing Factor to the Thyrotrophin-releasing Receptor: the Pyroglutamic Acid Moiety
Overview
Pharmacology
Affiliations
The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors.
Vu O, Bender B, Pankewitz L, Huster D, Beck-Sickinger A, Meiler J Molecules. 2022; 27(1).
PMID: 35011444 PMC: 8746363. DOI: 10.3390/molecules27010210.
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.
Kehlen A, Haegele M, Bohme L, Cynis H, Hoffmann T, Demuth H Biosci Rep. 2017; 37(4).
PMID: 28739588 PMC: 5634468. DOI: 10.1042/BSR20170712.
Shih Y, Chou C, Chen Y, Huang K, Wang A PLoS One. 2014; 9(4):e94812.
PMID: 24733552 PMC: 3986218. DOI: 10.1371/journal.pone.0094812.
Huang K, Hsu H, Karim S, Wang A Acta Crystallogr D Biol Crystallogr. 2014; 70(Pt 3):789-801.
PMID: 24598748 PMC: 8494195. DOI: 10.1107/S1399004713033488.
Rong M, Duan Z, Chen J, Li J, Xiao Y, Liang S PLoS One. 2013; 8(6):e65984.
PMID: 23826086 PMC: 3691182. DOI: 10.1371/journal.pone.0065984.