Granular Cell Tumor of the Esophagus--report of a Case and Review of the Literature

Overview

Journal Jpn J Surg

Specialty General Surgery

Date 1991 Jul 1

PMID 1960903

Citations 1

Authors

N Tohnosu

Y Matsui

M Ozaki

Y Koide

K Okuyama

T Kouzu

S Onoda

K Isono

H Horie

Affiliations

Soon will be listed here.

Abstract

We report herein a case of a 46 year old man presenting with a gastric ulcer in whom an endoscopy happened to detect an elevated lesion in the lower esophagus. Endoscopic biopsy proved sufficient for determining the diagnosis of a granular cell tumor (GCT). Electron and microscopic studies suggest that GCT are derived from Schwann cells. Although commonly found in the tongue and skin, GCT are rarely seen in the gastrointestinal tract, especially in the esophagus. However, advances in endoscopic techniques will increase the opportunity of detecting GCT of the esophagus.

Citing Articles

Granular cell tumor of the pancreas: A case report and review of literature.

Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H World J Gastrointest Oncol. 2010; 2(2):121-4.

PMID: 21160931 PMC: 2999167. DOI: 10.4251/wjgo.v2.i2.121.

References

Stefansson K, Wollmann R . S-100 protein in granular cell tumors (granular cell myoblastomas). Cancer. 1982; 49(9):1834-8. DOI: 10.1002/1097-0142(19820501)49:9<1834::aid-cncr2820490916>3.0.co;2-g. View

Brady P, NORD H, CONNAR R . Granular cell tumor of the esophagus: natural history, diagnosis, and therapy. Dig Dis Sci. 1988; 33(10):1329-33. DOI: 10.1007/BF01536687. View

FLOOD C . Granular cell tumor of the esophagus. Gastrointest Endosc. 1981; 27(4):225-7. DOI: 10.1016/s0016-5107(81)73228-0. View

PETERSON Jr P, Soule E, BERNATZ P . Benign granular-cell myoblastoma of the bronchus: report of two cases. J Thorac Surg. 1957; 34(1):95-104. View

OBIDITSCH-MAYER I, SALZER-KUNTSCHIK M . [Malignant "granular cell neuroma", so-called "myoblastmyoma" of the esophagus]. Beitr Pathol Anat. 1961; 125:357-73. View

Murata Y, Yoshida M, Akimoto S, Ide H, Suzuki S, Hanyu F . Evaluation of endoscopic ultrasonography for the diagnosis of submucosal tumors of the esophagus. Surg Endosc. 1988; 2(2):51-8. DOI: 10.1007/BF00704350. View

MOSCOVIC E, AZAR H . Multiple granular cell tumors ("myoblastomas"). Case report with electron microscopic observations and review of the literature. Cancer. 1967; 20(11):2032-47. DOI: 10.1002/1097-0142(196711)20:11<2032::aid-cncr2820201133>3.0.co;2-w. View

Fisher E, Wechsler H . Granular cell myoblastoma--a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer. 1962; 15:936-54. DOI: 10.1002/1097-0142(196209/10)15:5<936::aid-cncr2820150509>3.0.co;2-f. View

Cooper P, Goodman M . Multilayering of the capillary basal lamina in the granular cell tumor. A marker of cellular injury. Hum Pathol. 1974; 5(3):327-38. DOI: 10.1016/s0046-8177(74)80115-2. View

10.

Coutinho D, Soga J, Yoshikawa T, Miyashita K, Tanaka O, Sasaki K . Granular cell tumors of the esophagus: a report of two cases and review of the literature. Am J Gastroenterol. 1985; 80(10):758-62. View

11.

Giacobbe A, Facciorusso D, Conoscitore P, Spirito F, Squillante M, Bisceglia M . Granular cell tumor of the esophagus. Am J Gastroenterol. 1988; 83(12):1398-400. View

12.

Ohmori T, Arita N, Uraga N, TABEI R, Tani M, Okamura H . Malignant granular cell tumor of the esophagus. A case report with light and electron microscopic, histochemical, and immunohistochemical study. Acta Pathol Jpn. 1987; 37(5):775-83. View

13.

Bayerdorffer E, OTTENJANN R . Granular cell tumor in upper GI-tract endoscopy. Five cases of esophageal location. Endoscopy. 1986; 18(3):97-100. DOI: 10.1055/s-2007-1018341. View

14.

Farrell K, DEVINE K, HARRISON Jr E, Olsen A . Granular cell myoblastoma of the esophagus. Incidence and surgical treatment. Ann Otol Rhinol Laryngol. 1973; 82(6):784-9. DOI: 10.1177/000348947308200606. View

15.

Sandler R, Wood D, Bozymski E . Endoscopic removal of a granular cell tumor of the esophagus. Gastrointest Endosc. 1981; 27(2):70-2. DOI: 10.1016/s0016-5107(81)73154-7. View

16.

Sobel H, Marquet E, AVRIN E, Schwarz R . Granular cell myoblastoma. An electron microscopic and cytochemical study illustrating the genesis of granules and aging of myoblastoma cells. Am J Pathol. 1971; 65(1):59-78. PMC: 2047508. View

17.

Lack E, Worsham G, Callihan M, Crawford B, Klappenbach S, Rowden G . Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol. 1980; 13(4):301-16. DOI: 10.1002/jso.2930130405. View

18.

Murray M . Cultural characteristics of three granular-cell myoblastomas. Cancer. 1951; 4(4):857-65. DOI: 10.1002/1097-0142(195107)4:4<857::aid-cncr2820040423>3.0.co;2-g. View

19.

Cornish D, Feinstat T, Schneider P, RUEBNER B, Trudeau W . Esophageal granular cell tumor removed by endoscopic polypectomy. Am J Gastroenterol. 1985; 80(12):950-3. View

20.

Rubesin S, Herlinger H, Sigal H . Granular cell tumors of the esophagus. Gastrointest Radiol. 1985; 10(1):11-5. DOI: 10.1007/BF01893063. View