Immunomodulatory Activities of the Ethanolic Extract of Caesalpinia Bonducella Seeds

Unlabelled: Caesalpinia bonducella FLEMING (Caesalpiniaceae) is a plant well known for its medicinal value in Indian Ayurveda. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial.

Aims Of The Study: The present study involved the investigation of immunomodulatory activities of ethanolic extract of Caesalpinia bonducella seeds.

Materials And Methods: Neutrophil adhesion test, haemagglutinating antibody (HA) titre, delayed-type hypersensitivity (DTH) response, phagocytic activity and cyclophosphamide-induced myelosuppression were determined by in vivo experiments.

Results: The evaluation of immunomodulatory potential by oral administration of ethanolic seed extract of Caesalpinia bonducella (200-500 mg/kg) evoked a significant increase in percent neutrophil adhesion to nylon fibers as well as a dose-dependent increase in antibody titre values, and potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells. Also it prevented myelosuppression in cyclophosphamide drug treated rats and good response towards phagocytosis in carbon clearance assay.

Conclusions: The results obtained in this study indicate that Caesalpinia bonducella possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.