The Role of Peroxisome Proliferator-activated Receptor Gamma in Blood Pressure Regulation

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2009 Jul 16

PMID 19602323

Citations 9

Authors

Milton Hamblin

Lin Chang

Jifeng Zhang

Y Eugene Chen

Affiliations

Soon will be listed here.

Abstract

Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily. It is expressed in adipocytes, immune cells, and cardiovascular cells that include cardiomyocytes, endothelial cells, and smooth muscle cells. PPARgamma plays a role in regulating cellular anti-inflammatory responses and is a mediator of insulin sensitization induced by thiazolidinediones, which also can reduce elevated blood pressure both clinically and experimentally. As a result, research regarding the role of PPARgamma in blood pressure homeostasis is ongoing. Recent studies have demonstrated that increases or decreases in blood pressure phenotype may be PPARgamma-dependent and involve a number of different signaling pathways. Furthermore, studies using PPARgamma mutant transgenic and knockout animal models provide further evidence regarding a role for endothelial-cell and vascular smooth muscle-cell PPARgamma in blood pressure regulation. However, there is a need for further research regarding PPARgamma--mediated mechanisms involved in maintaining physiologic control of blood pressure.

Citing Articles

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