Platelets: Guardians of Tumor Vasculature

Overview

Journal Cancer Res

Specialty Oncology

Date 2009 Jul 9

PMID 19584268

Citations 50

Authors

Benoit Ho-Tin-Noe

Tobias Goerge

Denisa D Wagner

Affiliations

Soon will be listed here.

Abstract

Solid tumors generate a prothrombotic environment capable of platelet activation. Recent findings indicate that the activated platelets are crucial regulators of tumor vascular homeostasis in that they prevent tumor hemorrhage. Surprisingly, this effect is independent of platelets' capacity to form thrombi and instead relies on the secretion of their granule content. Thus, targeting platelet secretory activities may represent a new approach to specifically destabilize tumor vasculature.

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