Influence of Anemia on Tumor Response to Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2009 Jul 8

PMID 19582465

Citations 16

Authors

Seong Dae Lee

Ji Won Park

Kui Seon Park

Seok-Byung Lim

Hee Jin Chang

Dae Yong Kim

Seung-Yong Jeong

Hyo Seong Choi

Jae Hwan Oh

Affiliations

Soon will be listed here.

Abstract

Purpose: In rectal cancer patients treated with preoperative chemoradiotherapy (CRT) and curative resection, we evaluated the influence of anemia on tumor response to preoperative CRT.

Methods: Between August 2001 and July 2007, 490 patients underwent preoperative CRT, followed by curative-intent surgery. Tumor responses were evaluated based on tumor regression grade (TRG), T- and N-level downstaging, and volume reduction rates.

Results: The level of pretreatment hemoglobin (Hb) was 12.9 +/- 1.7 g/dl (range, 7.2-17.6 g/dl). Tumor response rates were significantly different below and above the Hb level of 9.0 g/dl. Specifically, patients with Hb levels >or=9.0 g/dl achieved better tumor responses than those with Hb levels < 9.0 g/dl (rates of TRG 3 or 4-29.0% vs. 0%, p < 0.001). In addition, there is no differences in tumor response between the nontransfusion and transfusion groups of patients with Hb levels >or=9.0 g/dl (rates of TRG 3 or 4-29.1% vs. 23.1%, p = 0.445).

Conclusions: The serum Hb level could be a one of prognostic factors that influences the pathologic tumor response, and pretreatment anemia (below 9.0 g/dl of Hb) is associated with poor response to preoperative CRT.

Citing Articles

The Prognostic Significance of Preoperative Anemia in Gastric Cancer Patients.

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The measurement and modification of hypoxia in colorectal cancer: overlooked but not forgotten.

Fletcher T, Thompson A, Ashrafian H, Darzi A Gastroenterol Rep (Oxf). 2022; 10:goac042.

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Vascular calcification and response to neoadjuvant therapy in locally advanced rectal cancer: an exploratory study.

Knight K, Drami I, McMillan D, Horgan P, Park J, Jenkins J J Cancer Res Clin Oncol. 2021; 147(11):3409-3420.

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Anaemia and its effects on tumour regression grade and survival following chemotherapy in adenocarcinoma of the oesophagus.

Boucher A, Ng O, Saunders J, Acheson A, Parsons S J Gastrointest Oncol. 2018; 9(5):797-805.

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Effect of leukocyte alteration on treatment outcomes following preoperative chemoradiotherapy in patients with rectal cancer.

Kim T, Park W, Choi D, Park H, Kim S, Cho Y Radiat Oncol J. 2017; 35(3):217-226.

PMID: 29037019 PMC: 5647753. DOI: 10.3857/roj.2017.00269.

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