Structure and Signalling in the IL-17 Receptor Family

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2009 Jul 4

PMID 19575028

Citations 669

Authors

Sarah L Gaffen

Affiliations

Soon will be listed here.

Abstract

Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17 (T(H)17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease. IL-17A and its receptor (IL-17RA) are the founding members of a newly described family of cytokines and receptors that have unique structural features which distinguish them from other cytokine families. Research defining the signal transduction pathways induced by IL-17R family cytokines has lagged behind that of other cytokine families, but studies in the past 2 years have begun to delineate unusual functional motifs and new proximal signalling mediators used by the IL-17R family to mediate downstream events.

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