Fundus Autofluorescence in Type 2 Idiopathic Macular Telangiectasia: Correlation with Optical Coherence Tomography and Microperimetry

Overview

Journal Am J Ophthalmol

Specialty Ophthalmology

Date 2009 Jul 4

PMID 19573860

Citations 30

Authors

Wai T Wong

Farzin Forooghian

Zigurts Majumdar

Robert F Bonner

Denise Cunningham

Emily Y Chew

Affiliations

Soon will be listed here.

Abstract

Purpose: To use multiple imaging methods to investigate patients with type 2 idiopathic macular telangiectasia (IMT) at different disease severity stages so as to characterize and categorize disease progression through the full spectrum of disease phenotypes.

Design: Observational case series.

Methods: Twelve patients with type 2 IMT (22 eyes) examined with fundus photography, angiography, optical coherence tomography imaging, fundus autofluorescence (FAF), and microperimetry testing in an institutional setting.

Results: Eyes examined by multiple imaging methods were classified into 5 proposed categories (0 through 4): category 0 (fellow) eyes had normal results on all imaging methods. Category 1 eyes had increased foveal autofluorescence on FAF imaging as the only imaging abnormality. Category 2 eyes had increased foveal autofluorescence together with funduscopic and angiographic features typical of type 2 IMT. Category 3 eyes had additional evidence of foveal atrophy on optical coherence tomography, and category 4 eyes had all the above features plus clinically evident pigment clumping. FAF signal increased in intensity in the foveal region from category 0 through category 3, whereas category 4 eyes demonstrated a mixed pattern of increased and decreased FAF signal.

Conclusions: The findings here outline a sequence of progressive changes seen with multiple imaging methods in advancing stages of disease. Increase in foveal autofluorescence is an early anatomic change in type 2 IMT that may precede typical clinical and angiographic changes. Loss of macular pigment density in the fovea and a changing composition of fluorophores in the retinal pigment epithelium may underlie these changes on FAF in the fundus.

Citing Articles

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Relevance of multicolor imaging, its component channels, and fundus autofluorescence in describing macular telangiectasia type-2 (MacTel) lesion characteristics.

Chandran K, Giridhar A, Desai S, Gopalakrishnan M, Indu V, Sivaprasad S Indian J Ophthalmol. 2023; 72(Suppl 1):S125-S134.

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Venkatesh R, Nahata H, Reddy N, Mishra P, Mangla R, Yadav N J Curr Ophthalmol. 2023; 34(4):428-435.

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