Impact of Genetic Polymorphisms on the Smoking-related Risk of Periodontal Disease: the Population-based Study SHIP

Overview

Journal Tob Induc Dis

Date 2009 Jul 3

PMID 19570260

Citations 2

Authors

P Meisel

G Heins

L E Carlsson

J Giebel

U John

C Schwahn

T Kocher

Affiliations

Soon will be listed here.

Abstract

Periodontitis is a bacterial inflammatory disease leading to attachment loss with the consequence of tooth loss. There exists a multifactorial risk pattern including bacterial challenge, smoking, age, sex, diabetes, socio-economic and genetic factors. Smoking has the highest impact on the course of the disease modulated by all the other factors. Here, we report the relationship between smoking and the polymorphisms of genetic polymorphisms inflicted in the pathogenesis.In a randomly selected population-based study, 1083 subjects were typed for the polymorphisms of the IL-1 genotype, Fcgamma RIIIb receptor gene, myeloperoxidase and N-acetyltransferase (NAT2) and related to their periodontal state. Smoking behavior was assessed including present and past quality and quantity of smoking.There is a significant dose-effect relationship between the exposure to tobacco smoke and the extent of periodontal disease assessed as attachment loss and tooth loss. Moreover, there are gene-environmental interactions as subjects bearing variant genotypes show an enhanced smoking-associated risk of the disease modulated by these genotypes. In non-smokers, the impact of these genetic polymorphisms is mostly negligible.This study provides support for the hypothesis that subjects bearing genetic variants of polymorphically expressed phenotypes are at an increased risk of periodontitis when smoking. Mostly, this may be accomplished via the influence of smoking-related impairment on defense mechanisms rather than on the pathogenic pathways.

Citing Articles

The influence of gene presence/absence polymorphisms on the development of periodontal disease in smokers and non-smokers.

Mazurek-Mochol M, Majorczyk E, Banach J, Dembowska E, Kusnierczyk P, Safranow K Cent Eur J Immunol. 2018; 42(4):347-353.

PMID: 29472811 PMC: 5820974. DOI: 10.5114/ceji.2017.72796.

Destructive effects of smoking on molecular and genetic factors of periodontal disease.

Ojima M, Hanioka T Tob Induc Dis. 2010; 8:4.

PMID: 20170537 PMC: 2836317. DOI: 10.1186/1617-9625-8-4.

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