Invasive Aspergillosis of the Hand Caused by Aspergillus Ustus: a Case Report

Overview

Journal Hand (N Y)

Publisher Sage Publications

Specialties General Surgery
Orthopedics

Date 2009 Jul 2

PMID 19568818

Citations 4

Authors

Olushola Olorunnipa

Andrew Y Zhang

Catherine M Curtin

Affiliations

Soon will be listed here.

Abstract

This is a case report of a 61-year-old cardiac transplant patient who developed a disseminated infection involving the upper extremity with a rare fungus known as Aspergillus ustus. The patient was successfully treated with aggressive serial debridements, antifungal medications, and reduction of immunosuppression. With these interventions, the patient avoided amputation despite the aggressive nature of this infection.

Citing Articles

Deep Fungal Infections of the Upper Extremity - A Review.

Ditsios K, Katsimentzas T, Pitsilos C, Koukourikos I, Christidis P, Ditsios T Orthop Rev (Pavia). 2024; 16:94570.

PMID: 38469579 PMC: 10927313. DOI: 10.52965/001c.94570.

A genomics based discovery of secondary metabolite biosynthetic gene clusters in Aspergillus ustus.

Pi B, Yu D, Dai F, Song X, Zhu C, Li H PLoS One. 2015; 10(2):e0116089.

PMID: 25706180 PMC: 4338041. DOI: 10.1371/journal.pone.0116089.

Mixed fungal infection (Aspergillus, mucor, and Candida) of severe hand injury.

Obradovic-Tomasev M, Popovic A, Vuckovic N, Jovanovic M Case Rep Infect Dis. 2014; 2014:954186.

PMID: 24782933 PMC: 3978409. DOI: 10.1155/2014/954186.

Emerging bacterial, fungal, and viral respiratory infections in transplantation.

Nishi S, Valentine V, Duncan S Infect Dis Clin North Am. 2010; 24(3):541-55.

PMID: 20674791 PMC: 7134700. DOI: 10.1016/j.idc.2010.04.005.

References

Grossman M, Fithian E, Behrens C, Bissinger J, Fracaro M, Neu H . Primary cutaneous aspergillosis in six leukemic children. J Am Acad Dermatol. 1985; 12(2 Pt 1):313-8. DOI: 10.1016/s0190-9622(85)80042-6. View

Saracli M, Mutlu F, Yildiran S, Kurekci A, Gonlum A, Uysal Y . Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an uncommon species. Med Mycol. 2007; 45(4):377-84. DOI: 10.1080/13693780701313803. View

Allo M, Miller J, Townsend T, Tan C . Primary cutaneous aspergillosis associated with Hickman intravenous catheters. N Engl J Med. 1987; 317(18):1105-8. DOI: 10.1056/NEJM198710293171802. View

Stiller M, Teperman L, Rosenthal S, Riordan A, Potter J, Shupack J . Primary cutaneous infection by Aspergillus ustus in a 62-year-old liver transplant recipient. J Am Acad Dermatol. 1994; 31(2 Pt 2):344-7. DOI: 10.1016/s0190-9622(94)70169-5. View

McCarty J, Flam M, Pullen G, Jones R, KASSEL S . Outbreak of primary cutaneous aspergillosis related to intravenous arm boards. J Pediatr. 1986; 108(5 Pt 1):721-4. DOI: 10.1016/s0022-3476(86)81051-4. View

Iwen P, Rupp M, Bishop M, Rinaldi M, Sutton D, Tarantolo S . Disseminated aspergillosis caused by Aspergillus ustus in a patient following allogeneic peripheral stem cell transplantation. J Clin Microbiol. 1998; 36(12):3713-7. PMC: 105272. DOI: 10.1128/JCM.36.12.3713-3717.1998. View

Goldberg B, Eversmann W, Eitzen Jr E . Invasive aspergillosis of the hand. J Hand Surg Am. 1982; 7(1):38-42. DOI: 10.1016/s0363-5023(82)80011-7. View

Bretagne S, Kuentz M, Latge J, Bart-Delabesse E, Cordonnier C . Serum Aspergillus galactomannan antigen testing by sandwich ELISA: practical use in neutropenic patients. J Infect. 1997; 35(1):7-15. DOI: 10.1016/s0163-4453(97)90833-1. View

Denning D, Stevens D . Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev Infect Dis. 1990; 12(6):1147-201. DOI: 10.1093/clinids/12.6.1147. View

10.

Varga J, Houbraken J, van der Lee H, Verweij P, Samson R . Aspergillus calidoustus sp. nov., causative agent of human infections previously assigned to Aspergillus ustus. Eukaryot Cell. 2008; 7(4):630-8. PMC: 2292628. DOI: 10.1128/EC.00425-07. View

11.

Vagefi P, Cosimi A, Ginns L, Kotton C . Cutaneous Aspergillus ustus in a lung transplant recipient: emergence of a new opportunistic fungal pathogen. J Heart Lung Transplant. 2008; 27(1):131-4. DOI: 10.1016/j.healun.2007.09.020. View

12.

Hunt S, Nagi C, Gross K, Wong D, Mathews W . Primary cutaneous aspergillosis near central venous catheters in patients with the acquired immunodeficiency syndrome. Arch Dermatol. 1992; 128(9):1229-32. View

13.

Jones N, Conklin W, Albo V . Primary invasive aspergillosis of the hand. J Hand Surg Am. 1986; 11(3):425-8. DOI: 10.1016/s0363-5023(86)80156-3. View

14.

Walmsley S, Devi S, King S, Schneider R, Richardson S, Ford-Jones L . Invasive Aspergillus infections in a pediatric hospital: a ten-year review. Pediatr Infect Dis J. 1993; 12(8):673-82. DOI: 10.1097/00006454-199308000-00009. View

15.

Estes S, Hendricks A, Merz W, Prystowsky S . Primary cutaneous aspergillosis. J Am Acad Dermatol. 1980; 3(4):397-400. DOI: 10.1016/s0190-9622(80)80334-3. View

16.

Balajee S, Houbraken J, Verweij P, Hong S, Yaghuchi T, Varga J . Aspergillus species identification in the clinical setting. Stud Mycol. 2008; 59:39-46. PMC: 2275201. DOI: 10.3114/sim.2007.59.05. View

17.

Carlile J, Millet R, Cho C, Vats T . Primary cutaneous aspergillosis in a leukemic child. Arch Dermatol. 1978; 114(1):78-80. View

18.

Panackal A, Imhof A, Hanley E, Marr K . Aspergillus ustus infections among transplant recipients. Emerg Infect Dis. 2006; 12(3):403-8. PMC: 3291436. DOI: 10.3201/eid1203.050670. View

19.

Verweij P, van den Bergh M, Rath P, De Pauw B, Voss A, Meis J . Invasive aspergillosis caused by Aspergillus ustus: case report and review. J Clin Microbiol. 1999; 37(5):1606-9. PMC: 84848. DOI: 10.1128/JCM.37.5.1606-1609.1999. View

20.

Weiss L, Thiemke W . Disseminated Aspergillus ustus infection following cardiac surgery. Am J Clin Pathol. 1983; 80(3):408-11. DOI: 10.1093/ajcp/80.3.408. View