Clinical Outcome of Breast Cancer Occurring After Treatment for Hodgkin's Lymphoma: Case-control Analysis

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2009 Jul 2

PMID 19566943

Citations 3

Authors

Mohamed A Alm El-Din

Kevin S Hughes

Rita A Raad

Saveli I Goldberg

Alan C Aisenberg

Andrzej Niemierko

Alphonse G Taghian

Affiliations

Soon will be listed here.

Abstract

Background: To evaluate diagnosis, management and outcome of breast cancer (BC) occurring after irradiation for Hodgkin's lymphoma (HL).

Methods: 39 cases of BC in 28 HL survivors were retrospectively reviewed. 21 patients were included in a case-control analysis.

Results: The median age at diagnosis of HL and BC was 25.3 and 45.3 years, respectively. The median interval to develop BC was 16.1 years. Eleven women (39.2%) had bilateral disease. Mode of detection of the index breast cancers was by mammographic screening in 17 patients (60.7%), palpable lump in 8 patients (28.6%), clinical examination in two patients (7.1%), and unknown in one patient (3.6%). Case-control analysis showed that histological features and prognosis of BC after HL were similar to those of primary BC, however, for BC after HL, mastectomy was the predominant surgery (P = .001) and adjuvant radiotherapy and anthracycline-based chemotherapy were less frequently used as compared to primary BC (P < .001 and .003, respectively).

Conclusion: The previous history of HL does not appear to be a poor prognostic factor for BC occurring thereafter.

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