Surrounding Rim Formation and Reduction in Size After Radiofrequency Ablation for Primary Breast Cancer

Overview

Journal Jpn J Radiol

Publisher Springer

Specialty Radiology

Date 2009 Jun 26

PMID 19554412

Citations 3

Authors

Takeshi Nagashima

Masahiro Sakakibara

Takafumi Sangai

Toshiki Kazama

Hiroshi Fujimoto

Masaru Miyazaki

Affiliations

Soon will be listed here.

Abstract

Purpose: Radiofrequency ablation (RFA) has recently been used to treat small breast cancer. However, there are no data on the long-term morphological features after the procedure. The present study attempts to clarify the characteristics of and changes in the ablated lesion.

Materials And Methods: A total of 17 breast cancer patients underwent RFA using a single needle featuring an internally cooled electrode; this was followed by whole-breast irradiation and adjuvant systemic therapy. Magnetic resonance imaging (MRI) using a 1.5-T system was performed before and 1, 3, 6, and 12 months after ablation, and the morphological characteristics and the size of the ablated lesion were evaluated. Mammography was also performed for a comparison with the MRI measurement.

Results: MRI displayed no residual enhancement of the tumor after RFA; there was an altered signal intensity with peripheral enhancement, however, and the area decreased in size gradually at a rate of 3.3% per month. Mammography showed a ring surrounding a roundish area whose size was equal to that seen with MRI.

Conclusion: Our current series demonstrated the morphological characteristics on breast imaging after RFA plus radiation therapy. The size of the ablated area decreased over time. These findings are valuable for clinical follow-up of breast cancer patients undergoing RFA.

Citing Articles

Magnetic resonance imaging-guided radiofrequency ablation of breast cancer: a current state of the art review.

Zhang C, Shi J, Li B, Yu X, Feng X, Yang H Diagn Interv Radiol. 2023; 30(1):48-54.

PMID: 36971252 PMC: 10773175. DOI: 10.4274/dir.2022.221429.

Efficacy and Safety of Radiofrequency Ablation for Breast Cancer Smaller Than 2 cm: A Systematic Review and Meta-Analysis.

Xia L, Hu Q, Xu W Front Oncol. 2021; 11:651646.

PMID: 34012918 PMC: 8126716. DOI: 10.3389/fonc.2021.651646.

Technical success, technique efficacy and complications of minimally-invasive imaging-guided percutaneous ablation procedures of breast cancer: A systematic review and meta-analysis.

Mauri G, Sconfienza L, Pescatori L, Fedeli M, Ali M, Di Leo G Eur Radiol. 2017; 27(8):3199-3210.

PMID: 28050693 DOI: 10.1007/s00330-016-4668-9.

References

Kontos M, Felekouras E, Fentiman I . Radiofrequency ablation in the treatment of primary breast cancer: no surgical redundancies yet. Int J Clin Pract. 2008; 62(5):816-20. DOI: 10.1111/j.1742-1241.2007.01676.x. View

Bloom K, Dowlat K, Assad L . Pathologic changes after interstitial laser therapy of infiltrating breast carcinoma. Am J Surg. 2001; 182(4):384-8. DOI: 10.1016/s0002-9610(01)00732-2. View

Medina-Franco H, Soto-Germes S, Ulloa-Gomez J, Romero-Trejo C, Uribe N, Ramirez-Alvarado C . Radiofrequency ablation of invasive breast carcinomas: a phase II trial. Ann Surg Oncol. 2008; 15(6):1689-95. DOI: 10.1245/s10434-008-9875-4. View

Burak Jr W, Agnese D, Povoski S, Yanssens T, Bloom K, Wakely P . Radiofrequency ablation of invasive breast carcinoma followed by delayed surgical excision. Cancer. 2003; 98(7):1369-76. DOI: 10.1002/cncr.11642. View

Marcy P, Magne N, Castadot P, Bailet C, Namer M . Ultrasound-guided percutaneous radiofrequency ablation in elderly breast cancer patients: preliminary institutional experience. Br J Radiol. 2006; 80(952):267-73. DOI: 10.1259/bjr/91383984. View

Noguchi M . Is radiofrequency ablation treatment for small breast cancer ready for "prime time"?. Breast Cancer Res Treat. 2007; 106(3):307-14. DOI: 10.1007/s10549-007-9515-x. View

Dian D, Schwenn K, Mylonas I, Janni W, Jaenicke F, Friese K . Aesthetic result among breast cancer patients undergoing autologous breast reconstruction versus breast conserving therapy. Arch Gynecol Obstet. 2006; 275(6):445-50. DOI: 10.1007/s00404-006-0270-8. View

Elmore J, Armstrong K, Lehman C, Fletcher S . Screening for breast cancer. JAMA. 2005; 293(10):1245-56. PMC: 3149836. DOI: 10.1001/jama.293.10.1245. View

Nagashima T, Sakakibara M, Nakamura R, Arai M, Kadowaki M, Kazama T . Dynamic enhanced MRI predicts chemosensitivity in breast cancer patients. Eur J Radiol. 2006; 60(2):270-4. DOI: 10.1016/j.ejrad.2006.07.014. View

10.

Bakker X, Roumen R . Bleeding after excision of breast lumps. Eur J Surg. 2002; 168(7):401-3. DOI: 10.1080/110241502320789087. View

11.

Goldberg S, Gazelle G, Mueller P . Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol. 2000; 174(2):323-31. DOI: 10.2214/ajr.174.2.1740323. View

12.

Quaranta V, Manenti G, Bolacchi F, Cossu E, Pistolese C, Buonomo O . FEM analysis of RF breast ablation: multiprobe versus cool-tip electrode. Anticancer Res. 2007; 27(2):775-84. View

13.

Izzo F, Thomas R, Delrio P, Rinaldo M, Vallone P, DeChiara A . Radiofrequency ablation in patients with primary breast carcinoma: a pilot study in 26 patients. Cancer. 2001; 92(8):2036-44. DOI: 10.1002/1097-0142(20011015)92:8<2036::aid-cncr1542>3.0.co;2-w. View

14.

Vlastos G, Verkooijen H . Minimally invasive approaches for diagnosis and treatment of early-stage breast cancer. Oncologist. 2007; 12(1):1-10. DOI: 10.1634/theoncologist.12-1-1. View

15.

Fornage B, Sneige N, Ross M, Mirza A, Kuerer H, Edeiken B . Small (< or = 2-cm) breast cancer treated with US-guided radiofrequency ablation: feasibility study. Radiology. 2004; 231(1):215-24. DOI: 10.1148/radiol.2311030651. View

16.

Ni Y, Chen F, Mulier S, Sun X, Yu J, Landuyt W . Magnetic resonance imaging after radiofrequency ablation in a rodent model of liver tumor: tissue characterization using a novel necrosis-avid contrast agent. Eur Radiol. 2006; 16(5):1031-40. DOI: 10.1007/s00330-005-0094-0. View

17.

Hamazoe R, Maeta M, Murakami A, Yamashiro H, Kaibara N . Heating efficiency of radiofrequency capacitive hyperthermia for treatment of deep-seated tumors in the peritoneal cavity. J Surg Oncol. 1991; 48(3):176-9. DOI: 10.1002/jso.2930480307. View

18.

Susini T, Nori J, Olivieri S, Livi L, Bianchi S, Mangialavori G . Radiofrequency ablation for minimally invasive treatment of breast carcinoma. A pilot study in elderly inoperable patients. Gynecol Oncol. 2006; 104(2):304-10. DOI: 10.1016/j.ygyno.2006.08.049. View

19.

Jeffrey S, Birdwell R, Ikeda D, Daniel B, Nowels K, Dirbas F . Radiofrequency ablation of breast cancer: first report of an emerging technology. Arch Surg. 1999; 134(10):1064-8. DOI: 10.1001/archsurg.134.10.1064. View

20.

Nagashima T, Suzuki M, Yagata H, Hashimoto H, Shishikura T, Imanaka N . Dynamic-enhanced MRI predicts metastatic potential of invasive ductal breast cancer. Breast Cancer. 2002; 9(3):226-30. DOI: 10.1007/BF02967594. View