Alkaline Reflux Oesophagitis

Overview

Journal Gut

Specialty Gastroenterology

Date 1991 Oct 1

PMID 1955159

Citations 10

Authors

D L Stoker

J G Williams

Affiliations

Soon will be listed here.

Abstract

Duodenal and gastric contents do reflux into the oesophagus and acid alone certainly causes oesophageal damage which will be worsened by pepsin. In the patient who has undergone gastrectomy duodenal secretions may also be harmful. There is evidence that when the two mix there may be a toxic synergism, leading to mucosal disruption and intracellular damage to oesophageal cells which produces the clinical picture of reflux oesophagitis, with or without symptoms. Clear evidence of the toxicity of duodenal refluxate in humans is lacking, but the ability to measure bile and acid reflux continuously, together with a method of detecting oesophageal damage at a cellular level should help to solve this long debated problem.

Citing Articles

Differences in the Characteristics of Barrett's Esophagus and Barrett's Adenocarcinoma between the United States and Japan.

Oryu M, Mori H, Kobara H, Nishiyama N, Fujihara S, Kobayashi M ISRN Gastroenterol. 2013; 2013:840690.

PMID: 23606979 PMC: 3625601. DOI: 10.1155/2013/840690.

Critical analysis of esophageal multichannel intraluminal impedance monitoring 20 years later.

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Increased risk of laryngeal and pharyngeal cancer after gastrectomy for ulcer disease in a population-based cohort study.

Lagergren J, Lindam A Br J Cancer. 2012; 106(7):1342-5.

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Quality of life in GERD patients: medical treatment versus antireflux surgery.

Ciovica R, Gadenstatter M, Klingler A, Lechner W, Riedl O, Schwab G J Gastrointest Surg. 2006; 10(7):934-9.

PMID: 16843863 DOI: 10.1016/j.gassur.2006.04.001.

Pathogenesis of columnar-lined esophagus.

Bani-Hani K, Bani-Hani B World J Gastroenterol. 2006; 12(10):1521-8.

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