Wildlife Cancer: a Conservation Perspective

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2009 Jun 25

PMID 19550426

Citations 65

Authors

Denise McAloose

Alisa L Newton

Affiliations

Soon will be listed here.

Abstract

Until recently, cancer in wildlife was not considered to be a conservation concern. However, with the identification of Tasmanian devil facial tumour disease, sea turtle fibropapillomatosis and sea lion genital carcinoma, it has become apparent that neoplasia can be highly prevalent and have considerable effects on some species. It is also clear that anthropogenic activities contribute to the development of neoplasia in wildlife species, such as beluga whales and bottom-dwelling fish, making them sensitive sentinels of disturbed environments.

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References

Van Bressem M, Cassonnet P, Rector A, Desaintes C, Van Waerebeek K, Alfaro-Shigueto J . Genital warts in Burmeister's porpoises: characterization of Phocoena spinipinnis papillomavirus type 1 (PsPV-1) and evidence for a second, distantly related PsPV. J Gen Virol. 2007; 88(Pt 7):1928-1933. DOI: 10.1099/vir.0.82694-0. View

Mukaratirwa S, Gruys E . Canine transmissible venereal tumour: cytogenetic origin, immunophenotype, and immunobiology. A review. Vet Q. 2003; 25(3):101-11. DOI: 10.1080/01652176.2003.9695151. View

Evermann J, Heeney J, McKeirnan A, OBrien S . Comparative features of a coronavirus isolated from a cheetah with feline infectious peritonitis. Virus Res. 1989; 13(1):15-27. PMC: 7133882. DOI: 10.1016/0168-1702(89)90084-1. View

Zhang Q, Wikoff J, Dunbar D, Kaminsky L . Characterization of rat small intestinal cytochrome P450 composition and inducibility. Drug Metab Dispos. 1996; 24(3):322-8. View

De Guise S, Lagace A, Beland P . Gastric papillomas in eight St. Lawrence beluga whales (Delphinapterus leucas). J Vet Diagn Invest. 1994; 6(3):385-8. DOI: 10.1177/104063879400600322. View

Hilker F, Langlais M, Malchow H . The Allee effect and infectious diseases: extinction, multistability, and the (dis-)appearance of oscillations. Am Nat. 2008; 173(1):72-88. DOI: 10.1086/593357. View

Herbst L, Klein P . Green turtle fibropapillomatosis: challenges to assessing the role of environmental cofactors. Environ Health Perspect. 1995; 103 Suppl 4:27-30. PMC: 1519284. DOI: 10.1289/ehp.95103s427. View

Gandhi M, Strong D . Donor derived malignancy following transplantation: a review. Cell Tissue Bank. 2007; 8(4):267-86. DOI: 10.1007/s10561-007-9036-1. View

Aguirre-Ghiso J . Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007; 7(11):834-46. PMC: 2519109. DOI: 10.1038/nrc2256. View

10.

Malins D, Krahn M, Myers M, Rhodes L, Brown D, Krone C . Toxic chemicals in sediments and biota from a creosote-polluted harbor: relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus). Carcinogenesis. 1985; 6(10):1463-9. DOI: 10.1093/carcin/6.10.1463. View

11.

De Guise S, Lagace A, Beland P . Tumors in St. Lawrence beluga whales (Delphinapterus leucas). Vet Pathol. 1994; 31(4):444-9. DOI: 10.1177/030098589403100406. View

12.

Ajithkumar T, Parkinson C, Butler A, Hatcher H . Management of solid tumours in organ-transplant recipients. Lancet Oncol. 2007; 8(10):921-32. DOI: 10.1016/S1470-2045(07)70315-7. View

13.

Memar O, Rady P, Tyring S . Human herpesvirus-8: detection of novel herpesvirus-like DNA sequences in Kaposi's sarcoma and other lesions. J Mol Med (Berl). 1995; 73(12):603-9. DOI: 10.1007/BF00196354. View

14.

Sweeney J, Gilmartin W . Survey of diseases in free-living California sea lions. J Wildl Dis. 1974; 10(4):370-6. DOI: 10.7589/0090-3558-10.4.370. View

15.

Kreiss A, Wells B, Woods G . The humoral immune response of the Tasmanian devil (Sarcophilus harrisii) against horse red blood cells. Vet Immunol Immunopathol. 2009; 130(1-2):135-7. DOI: 10.1016/j.vetimm.2009.02.003. View

16.

Kreiss A, Fox N, Bergfeld J, Quinn S, Pyecroft S, Woods G . Assessment of cellular immune responses of healthy and diseased Tasmanian devils (Sarcophilus harrisii). Dev Comp Immunol. 2007; 32(5):544-53. DOI: 10.1016/j.dci.2007.09.002. View

17.

Herbst L, Chakrabarti R, Klein P, Achary M . Differential gene expression associated with tumorigenicity of cultured green turtle fibropapilloma-derived fibroblasts. Cancer Genet Cytogenet. 2001; 129(1):35-9. DOI: 10.1016/s0165-4608(01)00421-6. View

18.

Martineau D, Lagace A, Beland P, Higgins R, Armstrong D, Shugart L . Pathology of stranded beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary, Québec, Canada. J Comp Pathol. 1988; 98(3):287-311. DOI: 10.1016/0021-9975(88)90038-2. View

19.

Muir D, Koczanski K, Rosenberg B, Beland P . Persistent organochlorines in beluga whales (Delphinapterus leucas) from the St Lawrence River estuary--II. Temporal trends, 1982-1994. Environ Pollut. 1996; 93(2):235-45. DOI: 10.1016/0269-7491(96)00008-5. View

20.

EPSTEIN R, Bennett B . Histocompatibility typing and course of canine venereal tumors transplanted into unmodified random dogs. Cancer Res. 1974; 34(4):788-93. View