A Novel Three-dimensional Image Reconstruction Method for Near-field Coded Aperture Single Photon Emission Computerized Tomography

Overview

Journal Med Phys

Specialty Biophysics

Date 2009 Jun 24

PMID 19544769

Citations 3

Authors

Zhiping Mu

Baoming Hong

Shimin Li

Yi-Hwa Liu

Affiliations

Soon will be listed here.

Abstract

Coded aperture imaging for two-dimensional (2D) planar objects has been investigated extensively in the past, whereas little success has been achieved in imaging 3D objects using this technique. In this article, the authors present a novel method of 3D single photon emission computerized tomography (SPECT) reconstruction for near-field coded aperture imaging. Multiangular coded aperture projections are acquired and a stack of 2D images is reconstructed separately from each of the projections. Secondary projections are subsequently generated from the reconstructed image stacks based on the geometry of parallel-hole collimation and the variable magnification of near-field coded aperture imaging. Sinograms of cross-sectional slices of 3D objects are assembled from the secondary projections, and the ordered subset expectation and maximization algorithm is employed to reconstruct the cross-sectional image slices from the sinograms. Experiments were conducted using a customized capillary tube phantom and a micro hot rod phantom. Imaged at approximately 50 cm from the detector, hot rods in the phantom with diameters as small as 2.4 mm could be discerned in the reconstructed SPECT images. These results have demonstrated the feasibility of the authors' 3D coded aperture image reconstruction algorithm for SPECT, representing an important step in their effort to develop a high sensitivity and high resolution SPECT imaging system.

Citing Articles

SPECT Imaging of 2-D and 3-D Distributed Sources with Near-Field Coded Aperture Collimation: Computer Simulation and Real Data Validation.

Mu Z, Dobrucki L, Liu Y J Med Biol Eng. 2016; 36:32-43.

PMID: 27069461 PMC: 4791458. DOI: 10.1007/s40846-016-0111-6.

Un-collimated single-photon imaging system for high-sensitivity small animal and plant imaging.

Walker K, Judenhofer M, Cherry S, Mitchell G Phys Med Biol. 2014; 60(1):403-20.

PMID: 25504038 PMC: 4560243. DOI: 10.1088/0031-9155/60/1/403.

Revisit of combined parallel-beam/cone-beam or fan-beam/cone-beam imaging.

Zeng G Med Phys. 2013; 40(10):100701.

PMID: 24089888 PMC: 3785539. DOI: 10.1118/1.4820373.

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