Modulation of Macrophage Tumoricidal Capability by Components of Normal Serum: a Central Role for Lipid

Overview

Journal Science

Specialty Science

Date 1977 Jul 15

PMID 195338

Citations 21

Authors

H A Chapman Jr

J B Hibbs Jr

Affiliations

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Abstract

The tumoricidal capabilities of macrophages can be reversibly inhibited by a lipoprotein of high molecular weight, and the inhibition appears to be reproduced by enrichment of macrophage plasma membranes with cholesterol. A second serum component of lower molecular weight enhances macrophage cytotoxicity. The presence of these components in normal serums suggests a physiological role for such factors in the regulation of macrophage function.

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