Cell Cycle Activation and CNS Injury

Overview

Journal Neurotox Res

Publisher Springer

Specialty Neurology

Date 2009 Jun 16

PMID 19526282

Citations 31

Authors

Bogdan A Stoica

Kimberly R Byrnes

Alan I Faden

Affiliations

Soon will be listed here.

Abstract

Although traditionally it was believed that adult neurons have entered a permanent post-mitotic phase, the latest experimental data indicate that cell cycle constituents critically affect normal functions of the adult central nervous system (CNS), as well as contribute to the pathophysiology of both acute and chronic neurodegenerative disorders. Recent study has also suggested that cell cycle pathways are involved in mediating not only neuronal cell death but also glial changes which may play key roles in the pathophysiological mechanisms underlying acute and chronic neurodegenerative disorders. Therefore, therapies that inhibit cell cycle may have robust neuroprotective profiles, particularly after acute insults, by targeting multiple pathogenic mechanisms and could be useful clinically if used with a delivery focused on specific areas and of a limited duration.

Citing Articles

RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus.

Zhao J, Wang W, Yan K, Zhao H, Zhang Z, Wang Y PeerJ. 2023; 11:e14913.

PMID: 36908815 PMC: 10000302. DOI: 10.7717/peerj.14913.

Neural Differentiation of Human-Induced Pluripotent Stem Cells (hiPSc) on Surface-Modified Nanofibrous Scaffolds Coated with Platelet-Rich Plasma.

Moazamiyanfar R, Halabian R, Ghollasi M, Poormoghadam D, Entezari M, Endorami S Neurochem Res. 2022; 47(7):1991-2001.

PMID: 35359243 DOI: 10.1007/s11064-022-03584-2.

Changes in Cyclin D1, cdk4, and Their Associated Molecules in Ischemic Pyramidal Neurons in Gerbil Hippocampus after Transient Ischemia and Neuroprotective Effects of Ischemic Preconditioning by Keeping the Molecules in the Ischemic Neurons.

Lee T, Kim D, Lee J, Park C, Sim H, Ahn J Biology (Basel). 2021; 10(8).

PMID: 34439951 PMC: 8389197. DOI: 10.3390/biology10080719.

Anti‑inflammatory mechanism of berberine on lipopolysaccharide‑induced IEC‑18 models based on comparative transcriptomics.

Xu X, Zhang L, Zhao Y, Xu B, Qin W, Yan Y Mol Med Rep. 2020; 22(6):5163-5180.

PMID: 33174609 PMC: 7646980. DOI: 10.3892/mmr.2020.11602.

Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions.

Jarrahi A, Braun M, Ahluwalia M, Gupta R, Wilson M, Munie S Biomedicines. 2020; 8(10).

PMID: 33003373 PMC: 7601301. DOI: 10.3390/biomedicines8100389.

References

Gabbita S, Lovell M, Markesbery W . Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J Neurochem. 1998; 71(5):2034-40. DOI: 10.1046/j.1471-4159.1998.71052034.x. View

Maeda M, Ampo K, Kiryu-Seo S, Konishi H, Ohba N, Kadono C . The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults. Exp Neurol. 2005; 193(2):350-60. DOI: 10.1016/j.expneurol.2005.01.018. View

Lundberg A, Weinberg R . Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol. 1998; 18(2):753-61. PMC: 108786. DOI: 10.1128/MCB.18.2.753. View

Biswas S, Liu D, Greene L . Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J Neurosci. 2005; 25(37):8349-58. PMC: 6725681. DOI: 10.1523/JNEUROSCI.1570-05.2005. View

Ueberham U, Arendt T . The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease. Curr Drug Targets CNS Neurol Disord. 2005; 4(3):293-306. DOI: 10.2174/1568007054038175. View

Adamec E, Vonsattel J, Nixon R . DNA strand breaks in Alzheimer's disease. Brain Res. 1999; 849(1-2):67-77. DOI: 10.1016/s0006-8993(99)02004-1. View

Sausville E . Complexities in the development of cyclin-dependent kinase inhibitor drugs. Trends Mol Med. 2002; 8(4 Suppl):S32-7. DOI: 10.1016/s1471-4914(02)02308-0. View

Romito-DiGiacomo R, Menegay H, Cicero S, Herrup K . Effects of Alzheimer's disease on different cortical layers: the role of intrinsic differences in Abeta susceptibility. J Neurosci. 2007; 27(32):8496-504. PMC: 6672937. DOI: 10.1523/JNEUROSCI.1008-07.2007. View

Herrup K, Neve R, Ackerman S, Copani A . Divide and die: cell cycle events as triggers of nerve cell death. J Neurosci. 2004; 24(42):9232-9. PMC: 6730083. DOI: 10.1523/JNEUROSCI.3347-04.2004. View

10.

Dhavan R, Greer P, Morabito M, Orlando L, Tsai L . The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci. 2002; 22(18):7879-91. PMC: 6758084. View

11.

Varvel N, Bhaskar K, Patil A, Pimplikar S, Herrup K, Lamb B . Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008; 28(43):10786-93. PMC: 2680286. DOI: 10.1523/JNEUROSCI.2441-08.2008. View

12.

Nahle Z, Polakoff J, Davuluri R, McCurrach M, Jacobson M, Narita M . Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol. 2002; 4(11):859-64. DOI: 10.1038/ncb868. View

13.

Schmetsdorf S, Gartner U, Arendt T . Constitutive expression of functionally active cyclin-dependent kinases and their binding partners suggests noncanonical functions of cell cycle regulators in differentiated neurons. Cereb Cortex. 2006; 17(8):1821-9. DOI: 10.1093/cercor/bhl091. View

14.

Park D, Morris E, Greene L, Geller H . G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis. J Neurosci. 1997; 17(4):1256-70. PMC: 6793728. View

15.

Strazza M, Luddi A, Brogi A, Carbone M, Riccio M, Santi S . Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes. Neurochem Res. 2004; 29(5):923-31. DOI: 10.1023/b:nere.0000021236.32785.37. View

16.

Faden A . Neuroprotection and traumatic brain injury: theoretical option or realistic proposition. Curr Opin Neurol. 2002; 15(6):707-12. DOI: 10.1097/01.wco.0000044767.39452.bf. View

17.

Byrnes K, Faden A . Role of cell cycle proteins in CNS injury. Neurochem Res. 2007; 32(10):1799-807. DOI: 10.1007/s11064-007-9312-2. View

18.

Rideout H, Wang Q, Park D, Stefanis L . Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition. J Neurosci. 2003; 23(4):1237-45. PMC: 6742273. View

19.

Nagy Z, Esiri M, Smith A . Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions. Acta Neuropathol. 1997; 93(3):294-300. DOI: 10.1007/s004010050617. View

20.

Greene L, Biswas S, Liu D . Cell cycle molecules and vertebrate neuron death: E2F at the hub. Cell Death Differ. 2003; 11(1):49-60. DOI: 10.1038/sj.cdd.4401341. View