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Serum Levels of Gastric-acid-stimulating Factors in Children Undergoing Open Heart Surgery

Overview
Journal Intensive Care Med
Specialty Critical Care
Date 2009 Jun 16
PMID 19526215
Citations 3
Authors
Christian Breuer
Manfred Rauh
Stefan Zink
Andreas Koch
Michael Weyand
Sven Dittrich
Henrik Kohler
Affiliations
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Abstract

Purpose: Upper gastrointestinal (GI) bleeding is a feared consequence of open heart surgery in children. Increased gastric acid secretion is a known key factor in the pathogenesis of gastritis and upper intestinal ulcerations. The aim of this study is to evaluate the serum kinetics of acid-stimulating factors and associated perioperative parameters after heart surgery in children.

Methods: Fifteen pediatric patients after open heart surgery and 15 children with cardiac catheterization were included in this study. Serum levels of gastrin, histidine, alanine, and tryptophan were analyzed before and up to 26 h after surgery.

Results: In the postoperative period there was a significant elevation of gastrin with a peak at 4 h after surgery. Serum histidine was increased significantly immediately after surgery only in patients undergoing heart surgery with cardioplegia. No association of gastrin and histidine elevation with ischemia, perfusion time or lactate was observed.

Conclusion: Factors that are responsible for postoperative gastrin elevation still have to be determined. Circumstances of extracorporeal circulation (ECC) in low-risk patients most likely do not lead to relevant elevation of amino acids with acid-stimulatory effect in our study population.

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Moderate Hypothermia Provides Better Protection of the Intestinal Barrier than Deep Hypothermia during Circulatory Arrest in a Piglet Model: A Microdialysis Study.

Liang M, Feng K, Yang X, Chen G, Tang Z, Lin W PLoS One. 2016; 11(9):e0163684.

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Year in review in Intensive Care Medicine 2009. Part III: mechanical ventilation, acute lung injury and respiratory distress syndrome, pediatrics, ethics, and miscellanea.

Antonelli M, Azoulay E, Bonten M, Chastre J, Citerio G, Conti G Intensive Care Med. 2010; 36(4):567-84.

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