Nuclear Imaging of Cancer Cell Therapies

Overview

Journal J Nucl Med

Specialty Nuclear Medicine

Date 2009 Jun 16

PMID 19525449

Citations 9

Authors

Vladimir Ponomarev

Affiliations

Soon will be listed here.

Abstract

A promising role of cellular therapies in cancer treatment is reflected by the constantly growing number of clinical trials with adoptively transferred cells. Direct and indirect cell labeling for the nuclear imaging of transferred cells has been proven reliable for imaging adoptive cellular therapies. Both methods show their advantages and limitations. Direct labeling is a relatively easy, inexpensive, and well-established methodology. Indirect labeling using a reporter gene imaging paradigm allows for reliable, stable, and harmless visualization of cellular trafficking, persistence, proliferation, and function at the target site. It is expected that new human-derived reporter genes will be rapidly translated into clinical applications that require repetitive imaging for the effective monitoring of various genetic and cellular therapies.

Citing Articles

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Li X, Yin G, Ji W, Liu J, Zhang Y, Wang J Onco Targets Ther. 2020; 13:11659-11668.

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Robust and automated three-dimensional segmentation of densely packed cell nuclei in different biological specimens with Lines-of-Sight decomposition.

Mathew B, Schmitz A, Munoz-Descalzo S, Ansari N, Pampaloni F, Stelzer E BMC Bioinformatics. 2015; 16:187.

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Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging.

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